Results 31 to 40 of about 192,126 (263)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessment of Heavy Metal Soil Contamination and Remediation Strategies in Eastern Slovakia: A Case Study from Dargov

Agriculture
Heavy metal contamination of agricultural soils represents a critical environmental and agronomic challenge, particularly in regions exposed to intensive land use and transport-related emissions.
Ivanna Betušová, Samer Khouri, Marian Šofranko, Andrea Šofranková, Miroslav Betuš   +4 more
doaj   +1 more source

Research of the Technical Seismicity Due to Blasting Works in Quarries and Their Impact on the Environment and Population

Applied Sciences, 2021
Vibrations caused by blasting works have an impact not only on buildings but also the internal environment of the buildings. If these buildings are situated in the surroundings of quarries, the citizens can perceive these vibrations negatively.
Jan Feher, Jozef Cambal, Blazej Pandula, Julian Kondela, Marian Sofranko, Tawfik Mudarri, Ivan Buchla   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Methods for Rescuing People Using Climbing Equipment in Abandoned Mines to Be Carried Out by Rescue Units of the Integrated Rescue System

Safety
This article discusses the possibilities and methods for rescuing people from abandoned mine workings and the cooperation of the components of the Integrated Rescue System of the Slovak Republic when carrying out rescue work in underground spaces ...
Marek Szücs, Miroslav Betuš, Martin Konček, Marian Šofranko, Andrea Šofranková   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Optimizing Emergency Response in Healthcare Facilities: Integration of Firefighting Technologies and Tactical Evacuation Strategies

Fire
This study analyzes the implementation of firefighting procedures and evacuation methods in a hospital environment, with a focus on ensuring rapid rescue operations and evacuation methods in a real fire in 2024.
Miroslav Betuš, Andrea Seňová, Annamária Behúnová, Ivanna Burachok, Galya Toteva Terzieva   +4 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

The identification of geosites as elements of geotourism offer in Kysuce region, Slovakia

Dela, 2017
The paper analyses the origin and evolution of the Kysuce landscape from the Mesozoic era until the arrival of humans, identifying the relics of these historical evolutionary stages in the present-day landscape. It presents the most important relics from
Pavel Hronček, Pavol Rybár, Ľubomír Štrba, Ladislav Hvizdák, Mário Molokáč, Miloš Jesenský   +5 more
doaj   +1 more source