Results 51 to 60 of about 259,067 (305)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A genetic programming based business process mining approach [PDF]
, 2009 As business processes become ever more complex there is a need for companies to understand the processes they already have in place. To undertake this manually would be time consuming.
Turner, Christopher J.
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
AgricultureHeavy metal contamination of agricultural soils represents a critical environmental and agronomic challenge, particularly in regions exposed to intensive land use and transport-related emissions.
Ivanna Betušová +4 more
doaj +1 more source
Handling concept drift in process mining
, 2011 Operational processes need to change to adapt to changing circumstances, e.g., new legislation, extreme variations in supply and demand, seasonal effects, etc.
Jagadeesh Chandra Bose, R.P. +5 more
core +1 more source
Interactive Process Mining in IoT and Human Behaviour Modelling
, 2020 [EN] In previous chapters, we saw how Interactive Process Mining (IPM) is key in discovering models from reality, while having a way of validating those models by the expert.
Ghassemian, Mona +9 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
SafetyThis article discusses the possibilities and methods for rescuing people from abandoned mine workings and the cooperation of the components of the Integrated Rescue System of the Slovak Republic when carrying out rescue work in underground spaces ...
Marek Szücs +4 more
doaj +1 more source
Energies, 2021 It is of great significance to ascertain the mechanical characteristics and deformation laws of tectonic coal that is under complex stress conditions for safe production, but the targeted research in this area is still insufficient at present. This paper
Deyi Gao +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source