Results 131 to 140 of about 950,688 (293)

Understanding the host-pathogen evolutionary balance through Gaussian process modeling of SARS-CoV-2. [PDF]

Patterns (N Y), 2023
Loguercio S, Calverley BC, Wang C, Shak D, Zhao P, Sun S, Budinger GRS, Balch WE.   +7 more
europepmc   +1 more source

Integrating Agile Development Processes and User Centred Design- A Place for Usability Maturity Models?

, 2014
Dina Salah, Richard F. Paige, Paul Cairns   +2 more
openalex   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Direct Compaction Drug Product Process Modeling. [PDF]

AAPS PharmSciTech, 2022
Russell A, Strong J, Garner S, Ketterhagen W, Long M, Capece M.   +5 more
europepmc   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Electrochemical Reduction of CO₂ to Oxalic Acid: Experiments, Process Modeling, and Economics. [PDF]

Ind Eng Chem Res, 2022
Boor V, Frijns JEBM, Perez-Gallent E, Giling E, Laitinen AT, Goetheer ELV, van den Broeke LJP, Kortlever R, de Jong W, Moultos OA, Vlugt TJH, Ramdin M.   +11 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Surgical Process Modeling for Open Spinal Surgeries. [PDF]

Front Surg, 2021
Carrillo F, Esfandiari H, Müller S, von Atzigen M, Massalimova A, Suter D, Laux CJ, Spirig JM, Farshad M, Fürnstahl P.   +9 more
europepmc   +1 more source

A model of learners profiles management process

, 2009
Carole Eyssautier-Bavay, Stéphanie Jean-Daubias, Jean-Philippe Pernin   +2 more
openalex   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source