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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
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Software Process Modeling: Principles Of Entity Process Models
11th International Conference on Software Engineering, 1989A defined software process is needed to provide organizations with a consistent framework for performing their work and im- proving the way they do it. An overall framework for modeling simplifies the task of producing process models, permits them to be tailored to individual needs, and facilitates process evolution.
Watts S. Humphrey, Marc I. Kellner
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Proceedings of the 23rd international conference on Machine learning - ICML '06, 2006
Abstract: "We introduce the Hidden Process Model (HPM), a probabilistic model for multivariate time series data intended to model complex, poorly understood, overlapping and linearly additive processes. HPMs are motivated by our interest in modeling cognitive processes given brain image data.
Rebecca A. Hutchinson +2 more
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Abstract: "We introduce the Hidden Process Model (HPM), a probabilistic model for multivariate time series data intended to model complex, poorly understood, overlapping and linearly additive processes. HPMs are motivated by our interest in modeling cognitive processes given brain image data.
Rebecca A. Hutchinson +2 more
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Business Modelling Is Not Process Modelling
2000Innovative e-business projects start with a design of the e-business model.We often encounter the view, in research as well as industry practice, that an e-business model is similar to a business process model, and so can be specified using UML activity diagrams or Petri nets. In this paper, we explain why this is a misunderstanding.
Jaap Gordijn +2 more
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IEEE Transactions on Systems, Man, and Cybernetics, 1972
Considerable interest currently exists in the application of the systems approach to the solution of societal, political, and environmental problems. The essence of this systems approach is modeling, the capability to describe large-scale complicated interactive systems by symbolic representations so that inferences regarding the effects of alternative
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Considerable interest currently exists in the application of the systems approach to the solution of societal, political, and environmental problems. The essence of this systems approach is modeling, the capability to describe large-scale complicated interactive systems by symbolic representations so that inferences regarding the effects of alternative
openaire +2 more sources
Tracing the Process of Process Modeling with Modeling Phase Diagrams
2012The quality of a business process model is presumably highly dependent upon the modeling process that was followed to create it. Still, there is a lack of concepts to investigate this connection empirically. This paper introduces the formal concept of a phase diagram through which the modeling process can be analyzed, and a corresponding implementation
Jakob Pinggera +6 more
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2005
In this section, we introduce the background to granulation modeling by posing the question, “Why model?'' and a further one, “How are models used in granulation systems technology?'' The following sections seek to answer these questions and demonstrate the benefits that can be derived from appropriate granulation process modeling.
Cameron, I. T., Wang, F. Y.
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In this section, we introduce the background to granulation modeling by posing the question, “Why model?'' and a further one, “How are models used in granulation systems technology?'' The following sections seek to answer these questions and demonstrate the benefits that can be derived from appropriate granulation process modeling.
Cameron, I. T., Wang, F. Y.
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Errors in the Process of Modeling Business Processes
2022Process models are the basic ingredient for many attempts to improve business processes. The graphical depiction of otherwise not observable behavior in an enterprise is one of the most important techniques in the digital society. They help to enable decision making in the design of processes and workflows.
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