Results 91 to 100 of about 7,124,786 (299)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Weld Formation in Laser Hot-Wire Welding of 7075 Aluminum Alloy
Metals, 2018 The laser hot-wire welding process was adopted to weld 7075 high-strength aluminum alloy. The influence laws of parameters on the weld formation were analyzed during laser hot-wire welding, and the microstructure characteristics and mechanical properties
Shichun Li, Wei Xu, Gang Xiao, Bing Chen
doaj +1 more source
Change Point Testing for the Drift Parameters of a Periodic Mean Reversion Process [PDF]
, 2013 In this paper we investigate the problem of detecting a change in the drift parameters of a generalized Ornstein-Uhlenbeck process which is defined as the solution of $dX_t=(L(t)-\alpha X_t) dt + \sigma dB_t$, and which is observed in continuous time. We
Dehling, Herold +3 more
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Journal of Manufacturing and Materials Processing, 2019 The aim of this study is to analyze the co-relation between the geometrical accuracy of parts formed by single-point incremental forming (SPIF) and the resulting distribution of the residual stresses induced in the material as a function of the different
Fawad Maqbool, Markus Bambach
doaj +1 more source
Determination of Terminal Sterilization Process Parameters [PDF]
Time, temperature, and microbial effects on terminal heat sterilization of ...
Hoffman, A. R., Stern, J. A.
core +1 more source
Two-lane traffic-flow model with an exact steady-state solution
, 2010 We propose a stochastic cellular-automaton model for two-lane traffic flow based on the misanthrope process in one dimension. The misanthrope process is a stochastic process allowing for an exact steady-state solution; hence we have an exact flow-density
Kanai, Masahiro
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source