Results 81 to 90 of about 15,701,455 (293)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

EXPLOSION POTENTIAL ASSESSMENT OF HEAT EXCHANGER NETWORK AT THE PRELIMINARY DESIGN STAGE [PDF]

Journal of Engineering Science and Technology, 2016
The failure of Shell and Tube Heat Exchangers (STHE) is being extensively observed in the chemical process industries. This failure can cause enormous production loss and have a potential of dangerous consequences such as an explosion, fire and toxic ...
MOHSIN PASHA, DZULKARNAIN ZAINI, AZMI MOHD SHARIFF   +2 more
doaj  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Lessons in Process Safety Management Learned in an Explosion Accident in Taiwan [PDF]

, 2016
PresentationA substantial explosion attributed to thermal decomposition of o,o-dimethyl phosphoramidothioate (DMPAT) resulted in 1 fatalities and 1 injury in Taichung, Taiwan, in 2016.
Liaw, Horng-Jang
core   +1 more source

Adaptive Hyperparameter-Tuned Transformer–LSTM for Lithium-Ion Battery State-of-Health Prediction

Batteries
Accurate prediction of lithium-ion battery state of health (SOH) is crucial for improving the safety, reliability, and operational efficiency of battery management systems (BMSs).
Xujing Chu, Siyu Deng, Nitin Roy, Bin Zhang   +3 more
doaj   +1 more source

Data-Driven Process Safety Analytics Using Transformer-Based Multimodal Machine Learning on OSHA Severe Injury Reports [PDF]

EPJ Web of Conferences
This study is aimed at advancing risk assessment and safety management by developing a Multi-Modal Machine Learning architecture capable of classifying injury incidences based on approximately 99,000 OSHA severe injury report records.
Afsheen Aafiya, Arumugasamy Muthulakshmi, Hassim Mimi H., Arumugasamy Senthil Kumar   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modeling the impact of safety climate on process safety in a modern process industry: The case of the UAE’s oil-refining industry

Cogent Business & Management, 2019
This study examines the psychometric properties of process safety and models the relationships between top management commitment to safety (Model 1), top management safety practices (Model 2), and supervisory safety behavior (Model 3). It is hypothesized
Mohamed Ali Al Mazrouei, Khalizani Khalid, Ross Davidson   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source