Results 41 to 50 of about 3,003,956 (306)

Software-Engineering Process Simulation (SEPS) model [PDF]

, 1992
The Software Engineering Process Simulation (SEPS) model is described which was developed at JPL. SEPS is a dynamic simulation model of the software project development process.
Abdel-Hamid, T., Lin, C. Y., Sherif, J. S.   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Temporal and spatial distribution, influencing factors and trend prediction of HIV/AIDS incidence among adolescents in Hubei province: an analysis on surveillance data of 2009 – 2019

Zhongguo gonggong weisheng, 2023
ObjectiveTo examine temporal and spatial distribution patterns and influencing factors of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic among adolescents in Hubei province, and to predict prevalence trend of the ...
Tao ZHANG, Jinbo YAN, Heng TANG
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Benefit Evaluation of Different Allocation Modes of Soil and Water Conservation Measures in Ta-pieh Mountains Area

Shuitu Baochi Xuebao
[Objective] In order to reveal the effect of different soil and water conservation measures on reducing runoff and sediment in Ta-pieh Mountains, optimize the allocation mode of soil and water conservation measures in Ta-pieh Mountains.
ZHOU Jie, TIAN Pei, WU Yijin, JIA Tinghui, SHEN Chenzhu   +4 more
doaj   +1 more source

PM_2.5 Pollution in Six Major Chinese Urban Agglomerations: Spatiotemporal Variations, Health Impacts, and the Relationships with Meteorological Conditions

Atmosphere, 2022
To investigate the spatiotemporal patterns of fine particulate matter (PM2.5) under years of control measures in China, a comprehensive analysis including statistical analysis, geographical analysis, and health impact assessment was conducted on millions
Zhuofan Li, Xiangmin Zhang, Xiaoyong Liu, Bin Yu   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Synergistic Zoning and Management Strategies for Ecosystem Service Value and Ecological Risk at the County Level: A Case Study of Songzi City, Hubei Province, China

Land
Counties are fundamental units for ecological restoration, where scientifically delineated zoning is essential for resource allocation and governance. This study proposes a dual-dimensional, multi-source ecological zoning framework combining ecosystem ...
Tingting Han, Jing Luo, Yilin Gan, Yaru Sun, Lingling Tian   +4 more
doaj   +1 more source

A Geographic Analysis on Rural Reconstruction-Transformation-Revitalization: A Case Study of Jianghan Plain in China

Land, 2022
At the beginning of the 21st century, with the rapid advancement of industrialization and urbanization, production factors such as population, capital, and land between urban and rural areas in China have gradually shifted to non-agricultural fields, the
Mingjie Wang, Bin Yu, Rongrong Zhuo, Zhuofan Li   +3 more
doaj   +1 more source