Results 41 to 50 of about 22,634,268 (292)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

An Experimental Investigation of Reactive Absorption of Carbon Dioxide into an Aqueous NH3/H2O/NaOH Solution [PDF]

Iranian Journal of Oil & Gas Science and Technology, 2017
In this research, the reactive absorption of carbon dioxide in an aqueous solution of NH3, H2O, and NaOH has experimentally been investigated. The experiments were carried out in an absorption pilot plant in different operational conditions.
Ahad Ghaemi, Vahid Hashemzadeh, Shahrokh Shahhosseini   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Temporal and spatial distribution, influencing factors and trend prediction of HIV/AIDS incidence among adolescents in Hubei province: an analysis on surveillance data of 2009 – 2019

Zhongguo gonggong weisheng, 2023
ObjectiveTo examine temporal and spatial distribution patterns and influencing factors of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic among adolescents in Hubei province, and to predict prevalence trend of the ...
Tao ZHANG, Jinbo YAN, Heng TANG
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Benefit Evaluation of Different Allocation Modes of Soil and Water Conservation Measures in Ta-pieh Mountains Area

Shuitu Baochi Xuebao
[Objective] In order to reveal the effect of different soil and water conservation measures on reducing runoff and sediment in Ta-pieh Mountains, optimize the allocation mode of soil and water conservation measures in Ta-pieh Mountains.
ZHOU Jie, TIAN Pei, WU Yijin, JIA Tinghui, SHEN Chenzhu   +4 more
doaj   +1 more source

PM_2.5 Pollution in Six Major Chinese Urban Agglomerations: Spatiotemporal Variations, Health Impacts, and the Relationships with Meteorological Conditions

Atmosphere, 2022
To investigate the spatiotemporal patterns of fine particulate matter (PM2.5) under years of control measures in China, a comprehensive analysis including statistical analysis, geographical analysis, and health impact assessment was conducted on millions
Zhuofan Li, Xiangmin Zhang, Xiaoyong Liu, Bin Yu   +3 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A modified method for estimating inherent strains from detailed process simulation for fast residual distortion prediction of single-walled structures fabricated by directed energy deposition

Additive Manufacturing, 2018
Predicting residual distortion in metal additive manufacturing (AM) is important to ensure quality of the fabricated component. The inherent strain method is ideal for this purpose, but has not been well developed for AM parts yet.
Xuan Liang, Lin Cheng, Qiang Chen, Qingcheng Yang, A. To   +4 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source