Results 61 to 70 of about 14,034,560 (296)
Communications Chemistry, 2023 Macrocycle peptides are promising constructs for imaging and inhibiting extracellular, and cell membrane proteins, but their use for targeting intracellular proteins is typically limited by poor cell penetration.
Arundhati Nag +8 more
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FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
LandCounties are fundamental units for ecological restoration, where scientifically delineated zoning is essential for resource allocation and governance. This study proposes a dual-dimensional, multi-source ecological zoning framework combining ecosystem ...
Tingting Han +4 more
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An Experimental Investigation of Reactive Absorption of Carbon Dioxide into an Aqueous NH3/H2O/NaOH Solution [PDF]
Iranian Journal of Oil & Gas Science and Technology, 2017 In this research, the reactive absorption of carbon dioxide in an aqueous solution of NH3, H2O, and NaOH has experimentally been investigated. The experiments were carried out in an absorption pilot plant in different operational conditions.
Ahad Ghaemi +2 more
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FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
LandInvestigating soil temperature and the heat transfer process is essential for understanding water–heat changes and energy balance in farmland. The conversion from upland fields (UFs) to paddy fields (PFs) alters the land cover, irrigation regimes, and ...
Jun Yi +10 more
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Zhongguo gonggong weisheng, 2023 ObjectiveTo examine temporal and spatial distribution patterns and influencing factors of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic among adolescents in Hubei province, and to predict prevalence trend of the ...
Tao ZHANG, Jinbo YAN, Heng TANG
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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