Results 71 to 80 of about 14,034,560 (296)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
LandSince the 21st century, rice–crayfish fields have been widely distributed in the Yangtze River Basin in China. However, the spontaneous construction of these fields by farmers has given rise to the issue of rice–crayfish field fragmentation (RCFF) in ...
Lei Shi, Xu He, Bo Hu, Jiuwei Li, Lei Yu
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Modeling and Simulation of a DiasporeTubular Digestion Process
, 2013 A simulation model is developed to predict the performance of a tubular digestion process of a low alumina/silica ratio diaspore bauxite type. The electrolyte - NRTL property method is used to calculate the equilibrium and thermodynamic properties of the
Farrokh, Mohammad, +2 more
core +1 more source
LandCultivated land health is fundamental to regional food security and sustainable agricultural development, particularly in hilly and mountainous areas where land fragmentation and natural constraints are pronounced.
Fenghao Song +4 more
doaj +1 more source
Simulation of Stimuli-Responsive Polymer Networks
Chemosensors, 2013 The structure and material properties of polymer networks can depend sensitively on changes in the environment. There is a great deal of progress in the development of stimuli-responsive hydrogels for applications like sensors, self-repairing materials ...
Thomas Gruhn, Heike Emmerich
doaj +1 more source
An Evaluation Model of Level of Detail Consistency of Geographical Features on Digital Maps
ISPRS International Journal of Geo-Information, 2020 This paper proposes a method to evaluate the level of detail (LoD) of geographic features on digital maps and assess their LoD consistency. First, the contour of the geometry of the geographic feature is sketched and the hierarchy of its graphical units ...
Pengcheng Liu, Jia Xiao
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
A Parallel Processing Approach to Dynamic Simulation of Ethylbenzene Process
, 2021 Parallel computing has been developed for many years in chemical process simulation. However, existing research on parallel computing in dynamic simulation cannot take full advantage of computer performance.
Junkai Zhang +3 more
core +1 more source