Results 111 to 120 of about 39,126 (300)

Processability and proficiency: Is there a causal relationship?

, 2019
The objective of this paper is to investigate if the relationship between the Processability Theory, a model for second language acquisition, and proficiency, is causal. The focus will be on attributive and predicative adjectival agreement.
Domenico Saracino, Antonio
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Processability theory and the acquisition of Japanese as a second language [PDF]

本稿ではProcessability theory(言語処理可能性理論: 筆者訳)の概要や理論的背景、第二言語習得研究等でどのような影響を及ぼしているか、また、この理論に対する批判等を考察しながら、Processability theoryの妥当性を概観した。更に、この理論を用いて行われた日本語の習得研究を紹介し、ここで示された日本語の発達段階を、Processability theoryを用いていない日本語習得研究の成果と比較、検証した。これまでの日本語の習得研究では、特に、｢は｣｢が｣の習得 ...
峯, 布由紀, MINE, Fuyuki
core  

Exploring the impact of high shear mixing process parameters on the physical characteristics of excipient powder blend by design of experiments

Acta Marisiensis - Seria Medica
Dry-route manufacturing technology development poses challenges to pharmaceutical technology research specialists, relying on active substance characteristics, excipient selection, and parameter optimization.
Kovács Béla, Tőkés Erzsébet Orsolya, Kelemen Éva Katalin, Zöldi Katalin, Suba Edit, Kovács-Deák Boglárka, Székely-Szentmiklósi István, Boda Francisc, Casian Tibor   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Improving the laser powder bed fusion processability of A2618 alloy: Investigation on TiB2 addition strategies via single scan track approach

Journal of Materials Research and Technology
Processing aluminum alloys by Laser Powder Bed Fusion (L-PBF) is of great interest for components production in various industries; however, their processability is quite challenging due to their susceptibility to solidification cracking.
Michele Rosito, Elisa Padovano, Stefano Felicioni, Matteo Vanzetti, Riccardo Casati, Joel Larsson, Federica Bondioli   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Machine-Learning Integration of Geophysical Responses for Predicting Metallurgical and Environmental Indicators in Mineral Systems

UMYU Scientifica Journal
The sustainability of mineral development increasingly depends on early understanding of ore processability and environmental behavior rather than ore grade alone.
Damilare Stephen Adepehin, Pauline Oluwatoyin Ijila, Adeyemi Paul Adesope, Elochukwu Emmanuel Okoye, Inalegwu Adoche Ngbede, Mary Tongha Ekwu   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source