Results 91 to 100 of about 218,041 (382)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A ghost imaging framework based on laser mode speckle pattern for underwater environments

Communications Engineering
Due to the complex physical processes found in underwater environments, such as absorption, scattering, and noise, it is challenging to obtain high-quality images using conventional camera-based imaging techniques.
Mo-Chou Yang, Peng Wang, Yi Wu, Guo-Ying Feng   +3 more
doaj   +1 more source

Geomorphological Characterization of the Colombian Orinoquia

Land
The Colombian Orinoquia was shaped within a tectonic and sedimentary framework linked to the uplift of the Andean cordilleras during the Oligocene–Miocene.
Larry Niño, Alexis Jaramillo-Justinico, Víctor Villamizar, Orlando Rangel, Vladimir Minorta-Cely, Daniel Sánchez-Mata   +5 more
doaj   +1 more source

Branching processes in near-critical random environments

, 2004
Branching processes are studied in random environments that are influenced by the population size and approach criticality as the population gets large.
Jagers, Peter, Jagers, Peter,, Klebaner, Fima C., Klebaner, Fima C.,   +3 more
core   +1 more source

Scaling limits of population and evolution processes in random environment

Electronic Journal of Probability, 2019
We propose a general method for investigating scaling limits of finite dimensional Markov chains to diffusions with jumps. The results of tightness, identification and convergence in law are based on the convergence of suitable characteristics of the chain
Vincent Bansaye, M. Caballero, S. Méléard   +2 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A simple stochastic model describing the evolution of genomic GC content in asexually reproducing organisms

Scientific Reports, 2022
A genome’s nucleotide composition can usually be summarized with (G)uanine + (C)ytosine (GC) or (A)denine + (T)hymine (AT) frequencies as GC% = 100% − AT%.
Jon Bohlin
doaj   +1 more source

Random walks in random environments without ellipticity

, 2013
We consider random walks in random environments on Z^d. Under a transitivity hypothesis that is much weaker than the customary ellipticity condition, and assuming an absolutely continuous invariant measure on the space of the environments, we prove the ...
LENCI, MARCO, Marco Lenci
core   +1 more source

A long-range contact process in a random environment [PDF]

, 2023
Benedikt Jahnel, Anh D. Vu
openalex   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source