Results 81 to 90 of about 218,041 (382)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Neural variability in the medial prefrontal cortex contributes to efficient adaptive behavior

Nature Communications
Neural variability, i.e. random fluctuations in neural activity, is a ubiquitous and sizable brain feature that impacts behavior. Its functional role however remains unclear and neural variability is commonly viewed as a nuisance factor degrading ...
Charles Findling, Margaux Romand-Monnier, Vasilisa Skvortsova, Etienne Koechlin   +3 more
doaj   +1 more source

MicroForest: Lightweight Bottleneck Prediction for Manufacturing Processes on Edge Devices

Applied Sciences
As digital transformation in manufacturing accelerates, process bottleneck prediction has emerged as a central task in industrial automation. To streamline manufacturing processes, where diverse tasks interact in complex ways, it is essential to identify
Seungmin Yoo, Chanyoung Oh
doaj   +1 more source

Integration of a Landsat Time-Series of NBR and Hydrological Modeling to Assess Pinus pinaster Aiton. Forest Defoliation in South-Eastern Spain

Remote Sensing, 2019
Climate change is increasing the vulnerability of Mediterranean coniferous plantations. Here, we integrate a Landsat time series with a physically-based distributed hydrological model (Watershed Integrated Management in Mediterranean Environments— ...
Antonio Jesús Ariza Salamanca, Rafael María Navarro-Cerrillo, Francisco J. Bonet-García, Ma José Pérez-Palazón, María J. Polo   +4 more
doaj   +1 more source

Random walk on the range of random walk [PDF]

We study the random walk X on the range of a simple random walk on ℤ d in dimensions d≥4. When d≥5 we establish quenched and annealed scaling limits for the process X, which show that the intersections of the original simple random walk path are ...
Croydon, David A.
core   +1 more source

On the maximum of a subcritical branching process in a random environment

Stochastic Processes and their Applications, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

An Improved Approach for Downscaling Coarse-Resolution Thermal Data by Minimizing the Spatial Averaging Biases in Random Forest

Remote Sensing, 2020
Land surface temperature (LST) plays a fundamental role in various geophysical processes at varying spatial and temporal scales. Satellite-based observations of LST provide a viable option for monitoring the spatial-temporal evolution of these processes.
Sammy M. Njuki, Chris M. Mannaerts, Zhongbo Su   +2 more
doaj   +1 more source

Occupation time theorems for one-dimensional random walks and diffusion processes in random environments

, 2009
The long time asymptotics of the time spent on the positive side are discussed for one-dimensional diffusion processes in random environments. The limiting distributions under the log–log scale are obtained for the diffusion processes in the stable ...
Kasahara, Yuji, Watanabe, Shinzo
core   +1 more source