Results 121 to 130 of about 218,041 (382)

Unraveling the origins of mobile antibiotic resistance genes using random forest classification of large-scale genomic data

Environment International
Understanding in which environments and under what conditions chromosomal antibiotic resistance genes (ARGs) acquire increased mobility is crucial to effectively mitigate their emergence in and dissemination among pathogens.
Stefan Ebmeyer, Erik Kristiansson, D. G. Joakim Larsson   +2 more
doaj   +1 more source

Spatial birth-and-death processes in random environment

, 2004
We consider birth-and-death processes of objects (animals) defined in ${\bf Z}^d$ having unit death rates and random birth rates. For animals with uniformly bounded diameter we establish conditions on the rate distribution under which the following holds for almost all realizations of the birth rates: (i) the process is ergodic with at worst power-law ...
Fernández, Roberto, Ferrari, Pablo A., Guerberoff, Gustavo R.   +2 more
openaire   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Hydrodynamic limit of simple exclusion processes in symmetric random environments via duality and homogenization [PDF]

, 2020
Alessandra Faggionato
openalex   +1 more source

Hydrodynamic limit of simple exclusion processes in symmetric random environments via duality and homogenization [PDF]

, 2022
Alessandra Faggionato
openalex   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Angular asymptotics for multi-dimensional non-homogeneous random walks with asymptotically zero drift

, 2009
We study the rst exit time from an arbitrary cone with apex at the origin by a non-homogeneous random walk (Markov chain) on Zd (d 2) with mean drift that is asymptotically zero.
MacPhee, Iain M., MacPhee, I.M., Menshikov, MV, Menshikov, Mikhail V., MacPhee, IM, Wade, AR, Wade, Andrew R., Wade, A.R.   +7 more
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

EPRNG: Effective Pseudo-Random Number Generator on the Internet of Vehicles Using Deep Convolution Generative Adversarial Network

Information
With the increasing connectivity and automation on the Internet of Vehicles, safety, security, and privacy have become stringent challenges. In the last decade, several cryptography-based protocols have been proposed as intuitive solutions to protect ...
Chenyang Fei, Xiaomei Zhang, Dayu Wang, Haomin Hu, Rong Huang, Zejie Wang   +5 more
doaj   +1 more source