Results 131 to 140 of about 172,960 (308)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Investigating fluctuation varieties in the propagation of the perturbed KdV equation with time-dependent perturbation coefficient

Partial Differential Equations in Applied Mathematics
This study investigates the perturbed Korteweg–de Vries equation modified by incorporating time-dependent perturbation coefficient to model random fluctuations within the wave dynamics.
Marwan Alquran
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Machine learning reveals microclimate-specific drivers of a cosmopolitan supervector's population dynamics

Ecological Informatics
Forecasting pest population dynamics under variable microclimates is essential for understanding and managing ecological interactions in agroecosystems.
Arinder K. Arora, Nolan Anderson, Kiran R. Gadhave   +2 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Three eruptions at the Fagradalsfjall Volcano in Iceland show rapid and predictable microbial community establishment

Communications Biology
How natural environments transition from uninhabited to inhabited is an incompletely understood question in ecology. We leverage the 2021–2023 Fagradalsfjall eruptions in Iceland as a natural experiment, tracking microbial colonization on the new lava ...
Nathan Hadland, Christopher W. Hamilton, Snædís Björnsdóttir, Solange Duhamel   +3 more
doaj   +1 more source

A survey of random number generator: Approaches, tests, novel applications in block-chain and AI driven industrial networks

Security and Safety
True Random Number Generators (TRNGs) are essential components in industrial systems and security-critical applications, providing non-deterministic randomness based on physical phenomena such as electronic noise, quantum effects, and biological ...
Chai Haozhe, Pan Qianqian, Wu Jun
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Random Forest-Based Method for Jet Concentration Prediction in Stratified Fluid Environments: Application and Comparison with Traditional Models [PDF]

In engineering fluid dynamics and environmental science, jet concentration prediction is a complex multivariable problem influenced by multiple factors.
Xiaohui Yan, Xiaoxue Chi, Sidi Liu, Liyan Lv, Ziming Song   +4 more
core   +1 more source