Results 151 to 160 of about 218,041 (382)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Investigating fluctuation varieties in the propagation of the perturbed KdV equation with time-dependent perturbation coefficient

Partial Differential Equations in Applied Mathematics
This study investigates the perturbed Korteweg–de Vries equation modified by incorporating time-dependent perturbation coefficient to model random fluctuations within the wave dynamics.
Marwan Alquran
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Machine learning reveals microclimate-specific drivers of a cosmopolitan supervector's population dynamics

Ecological Informatics
Forecasting pest population dynamics under variable microclimates is essential for understanding and managing ecological interactions in agroecosystems.
Arinder K. Arora, Nolan Anderson, Kiran R. Gadhave   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Three eruptions at the Fagradalsfjall Volcano in Iceland show rapid and predictable microbial community establishment

Communications Biology
How natural environments transition from uninhabited to inhabited is an incompletely understood question in ecology. We leverage the 2021–2023 Fagradalsfjall eruptions in Iceland as a natural experiment, tracking microbial colonization on the new lava ...
Nathan Hadland, Christopher W. Hamilton, Snædís Björnsdóttir, Solange Duhamel   +3 more
doaj   +1 more source

A survey of random number generator: Approaches, tests, novel applications in block-chain and AI driven industrial networks

Security and Safety
True Random Number Generators (TRNGs) are essential components in industrial systems and security-critical applications, providing non-deterministic randomness based on physical phenomena such as electronic noise, quantum effects, and biological ...
Chai Haozhe, Pan Qianqian, Wu Jun
doaj   +1 more source

Properties of multitype subcritical branching processes in random environment [PDF]

, 2021
Vladimir Vatutin, Elena Dyakonova
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source