Results 51 to 60 of about 589,178 (317)

The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study. [PDF]

PLoS ONE, 2015
To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks.We studied intracerebral recordings in patients ...
Klára Štillová, Pavel Jurák, Jan Chládek, Jan Chrastina, Josef Halámek, Martina Bočková, Sabina Goldemundová, Ivo Říha, Ivan Rektor   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Retrieval, monitoring, and control processes: a 7 tesla FMRI approach to memory accuracy

, 2013
Risius U-M, Staniloiu A, Piefke M, et al. Retrieval, monitoring, and control processes: a 7 tesla FMRI approach to memory accuracy. Frontiers in Behavioral Neuroscience. 2013;7: 24.MEMORY RESEARCH HAS BEEN GUIDED BY TWO POWERFUL METAPHORS: the storehouse
Piefke, Martina, Martina ePiefke, Matthias eBrand, Uda-Mareke Risius, Frank P. Schulte, Risius, Uda-Mareke, Schulte, Frank P., Frank eSchulte, Hans J. Markowitsch, Uda Mareike Risius, Brand, Matthias, Maderwald, Stefan, Angelica eStaniloiu, Stefan Maderwald, Staniloiu, Angelica, Angelica Staniloiu, Markowitsch, Hans J., Stefan eMaderwald, Martina Piefke, Matthias Brand   +19 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Is Working Memory Necessary for Both Selection and Calculation in Level 1 Visual Perspective Taking? Evidence from Children and Adults

Behavioral Sciences
Previous research has suggested that there are two modular processes of perspective selection and calculation in level 1 perspective taking. Evidence further showed that verbal working memory is associated with both processes in adults. However, research
Guifen He, Wei Song, Peiqi Dong, Canmei Xu, Yanlin Zhou, Haoqin Ye, Qiong Zhang   +6 more
doaj   +1 more source

Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep

Neural Plasticity, 2012
Age-related cognitive impairments often include difficulty retrieving memories, particularly those that rely on executive control. In this paper we discuss the influence of the prefrontal cortex on memory retrieval, and the specific memory processes ...
Kristine A. Wilckens, Kirk I. Erickson, Mark E. Wheeler   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Unlocking Neurocognitive Substrates of Late-Life Affective Symptoms Using the Research Domain Criteria: Worry Is an Essential Dimension

Frontiers in Aging Neuroscience, 2017
While investigations have sought to identify the distinct and shared contributions of anxiety and depression to neurocognitive processes in late life, less is known regarding the further contribution of worry, a unique and critical dimension of affective
Sherry A. Beaudreau, Sherry A. Beaudreau, Sherry A. Beaudreau, Nathan C. Hantke, Nathan C. Hantke, Nehjla Mashal, Nehjla Mashal, Christine E. Gould, Christine E. Gould, Victor W. Henderson, Victor W. Henderson, Ruth O'Hara, Ruth O'Hara, Ruth O'Hara   +13 more
doaj   +1 more source