Results 61 to 70 of about 78,174,087 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Subjective Experience of Episodic Memory and Metacognition: A Neurodevelopmental Approach [PDF]

, 2013
Episodic retrieval is characterized by the subjective experience of remembering. This experience enables the co-ordination of memory retrieval processes and can be acted on metacognitively.
Katalin Pauly-Takacs, Francis eEustache, Bérengère Guillery-Girard, Katalin ePauly-Takacs, Souchay, C, Eustache, F, Francis Eustache, Wojcik, DZ, Pauly-Takacs, K, Celine eSouchay, Berengere eGuillery-Girard, Dominika Zofia Wojcik, Guillery-Girard, B, Céline Souchay   +13 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Is Working Memory Necessary for Both Selection and Calculation in Level 1 Visual Perspective Taking? Evidence from Children and Adults

Behavioral Sciences
Previous research has suggested that there are two modular processes of perspective selection and calculation in level 1 perspective taking. Evidence further showed that verbal working memory is associated with both processes in adults. However, research
Guifen He, Wei Song, Peiqi Dong, Canmei Xu, Yanlin Zhou, Haoqin Ye, Qiong Zhang   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep

Neural Plasticity, 2012
Age-related cognitive impairments often include difficulty retrieving memories, particularly those that rely on executive control. In this paper we discuss the influence of the prefrontal cortex on memory retrieval, and the specific memory processes ...
Kristine A. Wilckens, Kirk I. Erickson, Mark E. Wheeler   +2 more
doaj   +1 more source

Unlocking Neurocognitive Substrates of Late-Life Affective Symptoms Using the Research Domain Criteria: Worry Is an Essential Dimension

Frontiers in Aging Neuroscience, 2017
While investigations have sought to identify the distinct and shared contributions of anxiety and depression to neurocognitive processes in late life, less is known regarding the further contribution of worry, a unique and critical dimension of affective
Sherry A. Beaudreau, Sherry A. Beaudreau, Sherry A. Beaudreau, Nathan C. Hantke, Nathan C. Hantke, Nehjla Mashal, Nehjla Mashal, Christine E. Gould, Christine E. Gould, Victor W. Henderson, Victor W. Henderson, Ruth O'Hara, Ruth O'Hara, Ruth O'Hara   +13 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Stochastic processes crossing from ballistic to fractional diffusion with memory: exact results

Condensed Matter Physics, 2010
We address the now classical problem of a diffusion process that crosses over from a ballistic behavior at short times to a fractional diffusion (sub- or super-diffusion) at longer times. Using the standard non-Markovian diffusion equation we demonstrate
V. Ilyin, I. Procaccia, A. Zagorodny
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source