Results 71 to 80 of about 711,244 (265)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Distributed Combinatorial Maps for Parallel Mesh Processing

open access: yesAlgorithms, 2018
We propose a new strategy for the parallelization of mesh processing algorithms. Our main contribution is the definition of distributed combinatorial maps (called n-dmaps), which allow us to represent the topology of big meshes by splitting them into ...
Guillaume Damiand   +3 more
doaj   +1 more source

Earth remote sensing data processing for obtaining vegetation types maps [PDF]

open access: yesКомпьютерная оптика, 2018
In this paper, we propose an earth remote sensing data processing technology for obtaining vegetation types maps. The technology includes the following steps: obtaining superpixel representation of an image, calculating superpixel features, K-Means ...
Anna Varlamova   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Hot Deformation Behavior of As-Cast 30Cr2Ni4MoV Steel Using Processing Maps

open access: yesMetals, 2017
The hot deformation behavior of as-cast 30Cr2Ni4MoV steel was characterized using processing maps in the temperature range 850 to 1200 °C and strain rate range 0.01 to 10 s−1.
Peng Zhou, Qingxian Ma, Jianbin Luo
doaj   +1 more source

Processing maps based on polymerization modelling of thick methacrylic laminates

open access: yesMaterials & Design, 2020
Control of the in-situ polymerization of thick methacrylic laminates is essential to minimize cavitation due to monomer boiling. To this end, a computationally efficient thermochemical model is developed to predict the temperature and degree of monomer ...
Sarah F. Gayot   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy