Results 101 to 110 of about 41,499 (247)

Predictive Markers for Hepatocellular Carcinoma Development in Patients with Chronic Hepatitis C Virus Genotype4a

Middle East Journal of Cancer, 2018
Background: Egypt has the highest prevalence of hepatitis C virus worldwide. Monitoring hepatitis C-infected patients for hepatocellular carcinoma development is an important clinical issue to diagnose these patients during the potentially curable ...
Ebtsam R. Zaher, Abeer A. Ghazal, Wael A. Ellabban, Mona El-Deeb, Lamyaa Al-Ghaleed   +4 more
doaj  

ADAMTS2: More than a procollagen N-proteinase

Genes and Diseases
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) is a member of the ADAMTS zinc metalloproteinase family, best known for its role as a procollagen I N-proteinase in the maturation of fibrillar collagens. Biallelic defects in the
Ruben Vanlerberghe, Alain Colige, Anne-Marie Malfait, Delfien Syx, Fransiska Malfait   +4 more
doaj   +1 more source

Integrative Identification of Anti‐Photoaging Peptides From Stress‐Tolerant Microorganisms via Machine Learning and KEAP1–NRF2 Docking

Journal of Peptide Science, Volume 32, Issue 8, August 2026.
Novel short‐chain peptides targeting the KEAP1‐NRF2 axis were identified through a multimodal discovery platform combining a stress‐tolerant microbial library with machine learning and molecular docking. These peptides regulate collagen synthesis and reduce MMP1/9 levels in human fibroblasts, providing significant protection against photoaging ...
Hanui Lee, Gyeong Han Jeong, Ji Wan Choi, Taehwan Kim, Younhee Shin, Jaewon Lim, Kwang‐Woo Jung, Byung Yeoup Chung, Seung Sik Lee   +8 more
wiley   +1 more source

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation

Scientific Reports, 2018
Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano, José Rodríguez-Nieves, Cory Colaneri, Justin Cotellessa, Diego Almanza, Alisa Zhilin-Roth, Todd Riley, Jill Macoska   +7 more
doaj   +1 more source

Acute GIP and GLP‐1 Administration Exerts Differential Metabolic Effects in Totally Pancreatectomised Individuals

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7280-7290, August 2026.
ABSTRACT Aims While being recognised for stimulating pancreatic insulin secretion, GIP and GLP‐1 exert various extrapancreatic effects relevant in the context of incretin‐based therapies. Here, we evaluated the extrapancreatic effects of GIP and GLP‐1, separately and combined, on postprandial physiology in totally pancreatectomised individuals ...
Liva S. L. Krogh, Maja B. Hansen, Natasha C. Bergmann, Carsten P. Hansen, Bolette Hartmann, Jens J. Holst, Filip K. Knop, Asger B. Lund, Lærke S. Gasbjerg   +8 more
wiley   +1 more source

Enhanced Liver Fibrosis Test, FIB‐4 and FibroScan: Real‐World Prognostic Accuracy for MASLD in a Biopsy‐Controlled Cohort

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims Liver fibrosis is a major determinant of liver‐related events (LREs) in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). Effective stratification based on fibrosis severity is essential for accurate prognosis.
Antonio Liguori, Francesca D'Ambrosio, Giulia Angelini, Consuelo Cefalo, Simone Galletti, Sara Cardinali, Maria Cristina Giustiniani, Giuseppe Marrone, Marco Biolato, Gianludovico Rapaccini, Maurizio Pompili, Antonio Grieco, Tommaso Mazza, Andrea Urbani, Maurizio Sanguinetti, Antonio Gasbarrini, FPG‐UCSC PROMETEO‐ELF substudy Research Group, Luca Miele   +17 more
wiley   +1 more source

Comparing the Short-Term Effect of Swimming Exercise and that of Curcumin Supplementation on Gene Expression of Laminin and Procollagen 3 in Liver of Male Rats Following Ethanol Abuse

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2019
Introduction:This study aimed to compare the short-term effect of swimming exercise and that of curcumin supplementation on gene expression of laminin and procollagen 3 in liver of male rats following ethanol abuse. Methods:In this study, 48 male Wistar
Hemmatfar A
doaj  

Effects of high‐fat diet and treadmill running on bone marrow fat and bone properties in young male mice

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract We investigated the effects of a high‐fat diet (HFD) and treadmill running on bone marrow fat (BMF) and bone properties in mice. Four‐week‐old male mice (n = 6/group) were assigned to four groups: standard diet (STD) or HFD (60% kcal from fat), under sedentary or exercise conditions.
Yuri Takamine, Noriko Ichinoseki‐Sekine, Takamasa Tsuzuki, Toshinori Yoshihara, Shuichi Machida, Hisashi Naito   +5 more
wiley   +1 more source

PCPE2: Expression of multifunctional extracellular glycoprotein associated with diverse cellular functions

Journal of Lipid Research
Procollagen C-endopeptidase enhancer 2, known as PCPE2 or PCOC2 (gene name, PCOLCE2) is a glycoprotein that resides in the extracellular matrix, and is similar in domain organization to PCPE1/PCPE, PCOC1 (PCOLCE1/PCOLCE).
Michael J. Thomas, Hao Xu, Angela Wang, Mirza Ahmar Beg, Mary G. Sorci-Thomas   +4 more
doaj   +1 more source

The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Meprin β overexpression is implicated in Alzheimer's Disease. Recent studies identified brevican as a meprin β substrate, and this study demonstrates that meprin α co‐expression enhances meprin β‐mediated brevican cleavage. Further, neurocan and RPTPζ were identified as novel meprin β substrates in an N‐terminomics analysis of meprin β transgenic mice,
Simon Kreiselmaier, Maximilian Keller, Leonardo Nardi, Constantin Mueller, Nele von Wiegen, Kira Bickenbach, Lea Gröbner, Mohammad Abukhalaf, Andreas Tholey, Margareta M. Mueller, Hagen Körschgen, Michael J. Schmeisser, Christoph Becker‐Pauly, Claus U. Pietrzik   +13 more
wiley   +1 more source