Results 41 to 50 of about 18,838 (296)

Checkpoint blockade and the stem‐like T cell trade‐off

open access: yesMolecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

The Bill of Rights and the Emerging Democracies [PDF]

open access: yes, 2002
Today, the influence of the US Bill of Rights can be traced through its remote offspring, including the Helsinki Agreement, the German Basic Law, the post-war French constitutions, and the European Convention on Human Rights.
Kurczewski, Jacek, Sullivan, Barry
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Exceptiones procuratoriae i cognitoriae

open access: yesCzasopismo Prawno-Historyczne, 1978
L'auteur fait l'analyse des exceptiones procuratoriae et cognitoriae à la base de la situation juridique du représentant de la partie (cognitor, procurator, tutor, curator, actor) dans le droit romain.
Władysław Rozwadowski
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Surtidor de fuente procedente de la vivienda de C. Ivlivs Silvanvs en Segobriga (Saelices, Cuenca, Conventus Carthaginensis)

open access: yesLucentum, 2003
En la campaña del año 1998 en Segobriga se excavó la vivienda del procurator C. Iulius Silvanus junto a las termas monumentales, construidas en época severiana.
Rosario Cebrián Fernández
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

A note on the St. John Co-Cathedral marble tombstones : the artisans, foreign and Maltese [PDF]

open access: yes, 1999
The aim of this brief study is to modestly review the documentation principally in the notarial archives concerning the tombstones, mainly in the period 1678 to 1819 and the marble craftsmen, local and foreign, who executed their masterpieces so expertly.
Debono, John
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Curator pontium

open access: yesBoletim de Estudos Clássicos
Fornecem as inscrições honoríficas as mais relevantes informações acerca do complexo e bem organizado sistema político-administrativo romano, porque, ao mostrarem o currículo das personalidades homenageadas, nos dão conta, por vezes, de funções ...
José d'Encarnação
doaj   +2 more sources

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