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Il Farmaco, 1999
An overview of the different heterocyclic NO-releasing compounds is given. Mesoionic heterocycles like sydnone imines are one example. This class is discussed on the synthesis and the mechanism of NO formation from Molsidomine and its first metabolite SIN-1.
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An overview of the different heterocyclic NO-releasing compounds is given. Mesoionic heterocycles like sydnone imines are one example. This class is discussed on the synthesis and the mechanism of NO formation from Molsidomine and its first metabolite SIN-1.
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Prodrugs in Cancer Chemotherapy
Xenobiotica, 1986At present, chemotherapy is not very effective against common solid cancers especially once they have metastasised. However, laboratory experiments and studies on dose intensification in humans have indicated that some anti-cancer agents might be curative but only if the dose given was very much higher than that presently obtainable clinically ...
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2023
A Prodrug is a specialized substance designed to contain the parent drug while remaining either inactive or only partially active. These molecules are intentionally engineered to undergo biotransformation within the body, either through chemical or enzymatic cleavage, in order to release the active compound at levels suitable for therapeutic effects ...
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A Prodrug is a specialized substance designed to contain the parent drug while remaining either inactive or only partially active. These molecules are intentionally engineered to undergo biotransformation within the body, either through chemical or enzymatic cleavage, in order to release the active compound at levels suitable for therapeutic effects ...
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Activation of Prodrugs Depend on the Metabolism of These Prodrugs
Current Research in Medical SciencesProdrugs depend on enzymatic processes, essentially in the liver, but can also occur in other tissues to release the active metabolite. These metabolic biotransformations are often enzymatically controlled, ensuring the drug becomes pharmacologically active at its site of action.
Rezk R. Ayyad +5 more
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Chemiexcitation‐Triggered Prodrug Activation for Targeted Carbon Monoxide Delivery
Angewandte Chemie - International Edition, 2022Qingqiang Min, Hengte Ke, Xingyue Ji
exaly
Presse medicale (Paris, France : 1983), 1988
Prodrugs are pharmacologically inert and nontoxic chemical compounds which are transformed in vivo into pharmacologically and therapeutically active compounds, i.e. drugs. Prodrugs are used to solve problems which cannot be solved by the drugs themselves.
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Prodrugs are pharmacologically inert and nontoxic chemical compounds which are transformed in vivo into pharmacologically and therapeutically active compounds, i.e. drugs. Prodrugs are used to solve problems which cannot be solved by the drugs themselves.
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