Results 161 to 170 of about 33,100 (295)

The Evolving Landscape of Hepatocellular Carcinoma Therapy: From Conventional Modalities to TME-Responsive Prodrug Design Strategies. [PDF]

Drug Des Devel Ther
Chen J, Yan H, Wang H, Li H, Wang Z, Ding Q, Zhu YZ.   +6 more
europepmc   +1 more source

Adverse Effects of Unsaturated Organic Compounds on Kinetic States During Locomotion Uncovered by Comprehensive Analysis of Behavioral Toxicities in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT Organisms in human living spaces are surrounded by a variety of engineered substances. These chemical compounds have unexpected effects on the environment and human health. In particular, workers in industries face the risk of a health hazard caused by high‐dose or long‐term exposure to chemicals in the workplace.
Masahiro Tomioka
wiley   +1 more source

Chemically Regulated STING-Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity. [PDF]

Angew Chem Int Ed Engl
Xie Z, Liu H, Yang Y, Sun X, Wang J, Liu T, Wang B, Qiu W, Sun Y, Bai Y, Zhang Y, Ma D, Xiang R, Li S, Xi Z.   +14 more
europepmc   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang, Hong‐Cheng Wei, Lin Jiang, Yi‐Sen Shao   +3 more
wiley   +1 more source

Molecular Docking and Molecular Dynamics Studies: Evaluation of the Potential Interaction between Ciprofloxacin-DAB-PAMAM Dendrimer-Based Prodrug Prototypes and Human Carboxylesterase 1. [PDF]

ACS Omega
Sueyoshi S, Raimo LB, Coutinho LP, Brito MOO, Giarolla J, Ducati LC.   +5 more
europepmc   +1 more source

Cathepsin Family Proteases in Prodrug Design: Recent Advances. [PDF]

ChemMedChem
Liu H, Zheng M, Ng CS, Loh TP.
europepmc   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

The Development of Four-Arm PEG-Based Thermoresponsive Dexamethasone Prodrugs for the Treatment of Osteoarthritis Pain. [PDF]

Nanomaterials (Basel)
Deng Y, Arash S, Rong J, Althobaiti SA, Liu S, Ransdell-Green E, Fehringer EV, Wang D.   +7 more
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Cellular signal-responsive m⁵C editing by an inducible split CRISPR platform. [PDF]

RNA
Dong C, Xu Y, Wu K, Mu N, Kumar S, Liang FS.   +5 more
europepmc   +1 more source