Results 141 to 150 of about 33,100 (295)
Clinical Pharmacology &Therapeutics, EarlyView.Drug dosing recommendations derived from healthy volunteers and selected preregistration populations may not translate reliably to physiologically distinct or understudied groups, particularly in low‐ and middle‐income countries. Using a metformin–dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate ...
Roland van Rensburg +2 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek +4 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.A decision model for the interpretation of chiral amphetamine analysis in hair was established based on the enantiomeric fraction (EF) of (S)‐amphetamine in authentic hair samples. Two chiral analysis methods (indirect/direct) were consecutively applied to distinguish between illicit and therapeutic amphetamine use in forensic cases.
Liesl K. Janssens +3 more
wiley +1 more source
Prodrugs of acyclic nucleoside phosphonates
Numerous modified nucleosides and nucleotides exhibit potent antiviral properties. The goal of this thesis was to synthesize ten novel prodrugs of acyclic nucleoside phosphonates, which contain 2,6-diaminopurine as a nucleobase, namely (R)-PMPDAP and (R)-
Jaroš, Marek
core
Novel prodrugs for enzyme prodrug gen therapy against tumor endothelium
, 2009 Novel prodrugs for enzyme prodrug gen therapy against tumor ...
Adam Patterson (1674628) +5 more
core
Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad +9 more
wiley +1 more source
A Nano-QSAR Model for the Cytotoxicity of Doxorubicin Prodrug Micelles in Multidrug-Resistant Cancer Cells. [PDF]
ACS OmegaKurian S, Santiago R.
europepmc +1 more source
The effect of anti‐seizure medications on exposure to statins: A systematic review and meta‐analysis
Epileptic Disorders, EarlyView.Abstract Objectives Antiseizure medications (ASMs) can reduce the efficacy of statin treatment, partly due to reduction in statin concentrations. In this systematic review and network meta‐analysis (NMA), we compared the effects of ASMs and the prototypical enzyme inducer rifampin on statin exposure.
Sharon Valiyev Huino +5 more
wiley +1 more source
Clarifying Problems in the Synthetic Pathway Towards Methylene-Type Levodopa Acylals as Potential Prodrugs. [PDF]
Arch Pharm (Weinheim)Keydel T, Theele Y, Link A.
europepmc +1 more source