Results 131 to 140 of about 73,540 (330)

Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs

Pharmaceutics
Background: Extracellular vesicles (EVs) can carry pathological cargo, contributing to disease progression. The enzyme neutral sphingomyelinase 2 (nSMase2) plays a critical role in EV biogenesis, making it a promising therapeutic target.
Arina Ranjit, Chae Bin Lee, Lukáš Tenora, Vijaya Saradhi Mettu, Arindom Pal, Jesse Alt, Barbara S. Slusher, Rana Rais   +7 more
doaj   +1 more source

Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy

Asian Journal of Pharmaceutical Sciences
The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of reducing substances (e.g., ascorbic ...
Mingyang Zhang, Yifan Miao, Can Zhao, Tong Liu, Xiyan Wang, Zixuan Wang, Wenxin Zhong, Zhonggui He, Chutong Tian, Jin Sun   +9 more
doaj   +1 more source

Prodrugs eller prodruger? [PDF]

Tidsskrift for Den norske legeforening, 2016
openaire   +1 more source

Platinum(IV) prodrugs

This chapter is an overview of recent progress in the design of Pt(IV) prodrugs. These kinetically-inert octahedral prodrugs can be reduced in cancer cells to active squareplanar Pt(II) complexes, for example by intracellular reducing agents such as ...
Sadler, P. J., Venkatesh, Venkatesh
core   +1 more source

Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers

European Journal of Medicinal Chemistry Reports
Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes.
Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski   +10 more
doaj   +1 more source

Synthesis of prodrugs of entacapone

, 2007
Die vorliegende Arbeit beschäftigt sich mit der Synthese von Prodrugs des Catechol-O-methyltransferase-Hemmstoffs Entacapon (Comtess®). Dieser wird in Kombination mit Levodopa und Decarboxylasehemmern in der Therapie des Morbus Parkinson verwendet.
Wehner, Katharina
core  

Glycosyl and polyalcoholic prodrugs of lonidamine

, 2008
Polyhydric alcohol derivatives of the anticancer agent lonidamine (LND) have been synthesized. The increased water solubility showed by prodrugs 4, 7, and 25 together with their logP values (2.19, 2.55, and 2.54, respectively) and chemical stability ...
SOZIO, Piera, CLAUDI F., CINQUE B, RUGGIERI S, DI STEFANO, Antonio, SANTONI G, GIORGIONI G, DI MARZIO, Luisa   +7 more
core   +1 more source

Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation

Cannabidiol (CBD 1) is a nonpsychotic cannabinoid-based drug approved by the U.S. FDA for treating refractory epilepsy, namely, Lennox–Gastaut and Dravet syndrome.
Varun Pratap Singh (17797380), Utpal Nandi (4656142), Parvinder Pal Singh (17797383), Lakhvinder Singh (10269909), Pankaj Singh Cham (17797377), Kuhu Sharma (11751396), Sumit Dhiman (12342841), Ajay Kumar (192967), Pankul Kotwal (8356383)   +8 more
core   +1 more source

Uncaging Iridium(III) Complexes for Combined Photodynamic and Photoactivated Chemotherapy

Angewandte Chemie International Edition, EarlyView.
Light‐activatable iridium(III) anticancer prodrugs demonstrate how chalcogen coordination controls photoinduced therapeutic activity. Upon visible‐light irradiation, sulfur‐ and selenium‐based caging ligands undergo distinct oxygen‐dependent photoreactions that trigger ligand release and singlet oxygen generation, enabling combined photoactivated ...
Victoria V. L. Müller, Dominik Moreth, Irene Regeni, Lan Wang, Sylvestre Bonnet, Ulrich Schatzschneider   +5 more
wiley   +1 more source

Ester prodrugs of flurbiprofen: Synthesis, plasma hydrolysis and gastrointestinal toxicity

, 2007
1164-1168Nine alkyl ester prodrugs of flurbiprofen have been synthesized with an aim to reduce it’s gastrointestinal side-effects. The synthesized prodrugs have been subjected to plasma hydrolysis and gastrointestinal toxicity studies.
Ramaa, C S, Rhea Mohan, C. S. Ramaa
core   +1 more source