Results 121 to 130 of about 33,100 (295)

New antiviral nucleoside prodrugs await application

, 2003
In this review, we intend to highlight outstanding concepts of antiviral nucleoside prodrugs which have been developed in recent years, so as to improve the efficacy of a given antiviral drug or to overcome some drug deficiencies.
Souard, Florence, Kraus, J.L., Anastasi, Carole, Burlet, Stéphane, Garino, Cédrik, Burlet, S., Garino, C., Kraus, Jean-Louis, Quelever, G., Souard, F., Quéléver, Gilles, Anastasi, C.   +11 more
core   +1 more source

Triangulation of dispensing and wastewater data for surveillance during lisdexamfetamine shortages: A descriptive time series analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Lisdexamfetamine, a long‐acting stimulant for attention‐deficit hyperactivity disorder (ADHD), has experienced widespread shortages in Australia since late 2023, raising concerns about treatment continuity and shifts in stimulant use patterns.
Jack Janetzki, Emma Keller, Nicole Pratt, Cobus Gerber, Lisa Kalisch Ellett   +4 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Platinum(IV) prodrugs

This chapter is an overview of recent progress in the design of Pt(IV) prodrugs. These kinetically-inert octahedral prodrugs can be reduced in cancer cells to active squareplanar Pt(II) complexes, for example by intracellular reducing agents such as ...
Sadler, P. J., Venkatesh, Venkatesh
core   +1 more source

Tenofovir diphosphate intracellular concentration following tenofovir alafenamide administration in bictegravir‐containing vs. dolutegravir‐containing antiretroviral regimens

British Journal of Clinical Pharmacology, EarlyView.
This study investigates intracellular (IC) exposure of tenofovir alafenamide (TAF) and its clinical determinants in experienced people living with HIV. We conducted a monocentric retrospective analysis of 86 adults treated with either bictegravir (BIC)‐ or dolutegravir (DTG)‐containing regimen. Plasma and IC trough concentrations (Ctrough) of tenofovir
Micol Ferrara, Viviana Maccario, Silvia Fantino, Erica Clemente, Federica Barrera, Alice Palermiti, Sara Soloperto, Amedeo De Nicolo, Antonio D'Avolio, Giovanni Di Perri, Stefano Bonora   +10 more
wiley   +1 more source

Study on the synthesis, physicochemical properties and transdermal absorption of scutellarein prodrugs

Scientific Reports
In this research, we aimed to improve the lipid solubility and transdermal absorbability of scutellarein through a prodrug strategy, and then improve its efficacy for treating psoriasis.
Ping Wang, Hong-jian Yu, Zhi-qi Yin, Chang-wei Zhou   +3 more
doaj   +1 more source

Synthesis of salicylanilide prodrugs [PDF]

, 2008
KRÁTKÝ, Martin. Synthesis of Salicylanilide Prodrugs. Hradec Králové: Faculty of Pharmacy of Charles University, 2008. 75 pp. Diploma Thesis. This diploma thesis is concerned with synthesis of antibacterial prodrugs based on esters of salicylanilides ...
Krátký, Martin
core  

Nitric Oxide Prodrugs:  Diazeniumdiolate Anions of Hindered Secondary Amines

, 2016
Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that α-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous ...
Harinath Chakrapani (1743040), Brett M. Showalter (1264689), Larry K. Keefer (1264698), Michael L. Citro (1264710), Joseph E. Saavedra (1264695)   +4 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Tailoring drug‐to‐lipid ratio in redox‐responsive lipid‐mimetic prodrug liposomes for superior cabazitaxel delivery and antitumor efficacy

BMEMat, EarlyView.
Redox‐responsive lipid‐mimetic prodrug liposomes with high drug‐to‐lipid ratios enhance cabazitaxel delivery, prolong circulation, and enable tumor‐selective drug release for superior antitumor efficacy and safety. Abstract Liposomes represent one of the most extensively investigated nanocarriers in drug delivery.
Shengyao Xu, Danping Wang, Si Zheng, Zhiyu Kuang, Ya Gao, Haiyu Zhao, Lurong Zhang, Jiayu Guo, Jingyi Zhang, Weiyao Li, Anhua Wang, Hongrui Lei, Zhonggui He, Ken‐ichiro Kamei, Jianzhao Niu, Lingyun Ma, Bingjun Sun   +16 more
wiley   +1 more source