Results 121 to 130 of about 73,540 (330)
Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie
Angewandte Chemie, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Development of Organic Carbon Monoxide prodrugs [PDF]
, 2019 Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals and may have signaling roles in bacteria as well. It has many recognized therapeutic effects.
Pan, Zhixiang
core +1 more source
A New Classification of Prodrugs: Regulatory Perspectives
Pharmaceuticals, 2009 Many therapeutic agents are manufactured and administered in prodrug forms. In this paper, a new classification system for prodrugs is proposed to provide useful information about where in the body a prodrug is converted to the active drug.
Kuei-Meng Wu
doaj +1 more source
A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
Asian Journal of Pharmaceutical Sciences, 2019 Monocarboxylate transporter 1 (MCT1) is responsible for oral absorption of short-chain monocarboxylic acids from small intestine, hence, it's likely to serve as an ideal design target for the development of oral prodrugs.
Yixin Sun +7 more
doaj +1 more source
Frontiers in ChemistryIntroduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer still lacking effective treatment options. Chemotherapy in combination with immunotherapy can restrict tumor progression and repolarize the tumor ...
Matilde Tubertini +14 more
doaj +1 more source
Molecules, 2014 A series of amino acid and dipeptide prodrugs of IMB-070593, a fluoroquinolone candidate discovered in our lab, were synthesized and evaluated for their water solubility and then antibacterial activity. Our results reveal that four amino acid prodrugs 4a,
Tingting Zhang +6 more
doaj +1 more source
Synthesis and Enzyme Hydrolysis Study of Acyloxyalkyl Carbamates as New Prodrugs for Amines
Al-Mustansiriyah Journal of Pharmaceutical SciencesIn this review, we examined studies through 2023 with particular attention to the cases listed below. by investigate the potential of acyloxyalkyl carbamates for the amine-containing drug in order to overcome problems associated with medication ...
Israa Abad Alrasol Mohamed Sadeq +3 more
doaj +1 more source
Design and Synthesis of Phosphotyrosine Peptidomimetic Prodrugs
, 2016 A novel approach to the intracellular delivery of aryl phosphates has been developed that utilizes a phosphoramidate-based prodrug approach. The prodrugs contain an ester group that undergoes reductive activation intracellularly with concomitant ...
Robert L. Geahlen (1325010) +3 more
core +1 more source
Angewandte Chemie, EarlyView.Lichtaktivierbare Iridium(III)‐Prodrugs zeigen, wie die Koordination von Chalkogenen die photoinduzierte therapeutische Aktivität steuert. Bei Bestrahlung mit sichtbarem Licht laufen an den schwefel‐ bzw. selenhaltigen Liganden unterschiedliche, sauerstoffabhängige Photoreaktionen ab.
Victoria V. L. Müller +5 more
wiley +1 more source
Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source