Results 101 to 110 of about 17,999,784 (345)
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
Scientific Reports, 2016 Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer’s disease (AD). The prevailing hypothesis on the disease etiopathogenesis is that oAβ initiates tau pathology that slowly ...
Mauro Fa’ +35 more
semanticscholar +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Nature, 2022 Donggi Paik +20 more
semanticscholar +1 more source
Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids.
Progress in lipid research, 2016 One of the most promising alternatives to petroleum for the production of fuels and chemicals is bio-oil based chemistry. Microbial oils are gaining importance because they can be engineered to accumulate lipids enriched in desired fatty acids.
Rodrigo Ledesma-Amaro, J. Nicaud
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Folia Horticulturae, 2009 The goal of this three-year study was to develop a quarantine-like treatment for two commercial sweet pepper (Capsicum annuum L.) cultivars, based on physical treatments and packaging materials, and to understand, in part, the chilling resistance-mode-of-
Fallik Elazar +6 more
doaj +1 more source
EVALUASI PEMASANGAN DAN PEMELIHARAAN ALAT PEMADAM API RINGAN DI GRESIK
The Indonesian Journal of Occupational Safety and Health, 2019 Oil and gas industry is an industry sector that has a high risk of fire. Fire is a potential hazard which can caused material loss, break of the production process and the danger to the human life safety.
Rizki Prasetya Wardana
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Jurnal Agrisep, 2004 This study was aimed at analysis rentability factors influencing production, investigating marketing channel of tempe industry in District of Sukaraja. Samples were selected purposively, i.e. small medium and large tempe industry which is measured
Nusril Nusril, M Nurung, Zuardi Zuardi
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source