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PhaLP: A Database for the Study of Phage Lytic Proteins and Their Evolution [PDF]
Viruses, 2021 Phage lytic proteins are a clinically advanced class of novel enzyme-based antibiotics, so-called enzybiotics. A growing community of researchers develops phage lytic proteins with the perspective of their use as enzybiotics.
Björn Criel +2 more
exaly +6 more sources
Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection [PDF]
Journal of Virology, 2022 The evidence for the presence of a diverse and abundant phage population in the host-associated oral microbiome came largely from metagenomic analysis or the observation of virus-like particles within saliva/plaque samples, while the isolation of oral phage and investigation of their interaction with bacterial hosts are limited.
Batbileg Bor +2 more
exaly +8 more sources
Viruses, 2019 Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic ...
Yves Briers
doaj +5 more sources
Phage lytic enzymes: a history
Virologica Sinica, 2015 There are many recent studies regarding the efficacy of bacteriophage-related lytic enzymes: the enzymes of 'bacteria-eaters' or viruses that infect bacteria. By degrading the cell wall of the targeted bacteria, these lytic enzymes have been shown to efficiently lyse Gram-positive bacteria without affecting normal flora and non-related bacteria. Recent
David Trudil
exaly +4 more sources
A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics. [PDF]
Infect Dis Poverty, 2022 Abstract Background Burkholderia pseudomallei is a tropical pathogen that causes melioidosis. Its intrinsic drug-resistance is a leading cause of treatment failure, and the few available antibiotics require prolonged use to be effective. This study aimed to assess the clinical potential of B. pseudomallei phages isolated
Wang Y +14 more
europepmc +5 more sources
Journal of Nepal Health Research Council, 2021 Background: Global emergence of carbapenem-resistant Klebsiella pneumoniae is a major public health concern. Phage therapy – application of lytic phage to kill pathogenic bacteria – is considered as one of the promising alternatives to tackle this ...
Gunaraj Dhungana +9 more
doaj +1 more source
The tripartite associations between bacteriophage, Wolbachia, and arthropods. [PDF]
PLoS Pathogens, 2006 By manipulating arthropod reproduction worldwide, the heritable endosymbiont Wolbachia has spread to pandemic levels. Little is known about the microbial basis of cytoplasmic incompatibility (CI) except that bacterial densities and percentages of ...
Seth R Bordenstein +4 more
doaj +2 more sources
Isolation and Identification of Escherichia coli O157:H7 Lytic Bacteriophage from Environment Sewage
International Journal of Food Science, 2021 Escherichia coli O157:H7 is one of the pathogenic bacteria causing foodborne disease. The use of lytic bacteriophages can be a good solution to overcome the disease.
Tessa Sjahriani +2 more
doaj +1 more source
Isolation and partial characterization of lytic phage against Salmonella Abortusequi
Veterinary World, 2013 Aim: To use partially characterized phages for generation of phage lysates having potential to be developed as vaccines against Salmonella Abortusequi. Material and Methods: Phage/s isolation from several sewage samples was attempted against Salmonella ...
Harshit Verma +5 more
doaj +1 more source
PLoS ONE, 2013 The increase in antibiotic resistance world-wide revitalized the interest in the use of phage lysins to combat pathogenic bacteria. In this work, we analyzed the specific cleavage sites on the staphylococcal peptidoglycan produced by three phage lytic ...
Lorena Rodríguez-Rubio +5 more
doaj +1 more source