Results 41 to 50 of about 30,001 (226)

Obtaining a lytic bacteriophage suitable for use in phage therapy against Clostridioides difficile infection [PDF]

, 2023
Clostridioides difficile is the leading cause of hospital-acquired and antibiotic-associated diarrhoea in the developed world. More effective countermeasures are required.
Kerr, Sarah
core   +1 more source

In Vitro Techniques and Measurements of Phage Characteristics That Are Important for Phage Therapy Success

Viruses, 2022
Validated methods for phage selection, host range expansion, and lytic activity determination are indispensable for maximizing phage therapy outcomes. In this review, we describe some relevant methods, highlighting their advantages and disadvantages, and
Tea Glonti, Jean-Paul Pirnay
doaj   +1 more source

Explaining microbial population genomics through phage predation

, 2009
The remarkable diversity of genes within the pool of prokaryotic genomes belonging to the same species or pan-genome is difficult to reconcile with the widely accepted paradigm which asserts that periodic selection within bacterial populations would ...
Lejla Pasic, T. Frede Thingstad, Francisco Rodriguez-Valera, Ana-Belén Martín-Cuadrado, Beltrán Rodriguez-Brito, Alex Mira, Forest Rohwer   +6 more
core   +1 more source

Biofilm spatial structure and superinfection immunity modulate inter-phage competition.

PLoS Biology
Obligately lytic (virulent) phages always lyse host cells to release progeny viruses, while temperate phages can either lyse their hosts or integrate into host genomes as prophages, forming lysogens.
James B Winans, Carey D Nadell
doaj   +1 more source

Structural and Biochemical Characterization of a New Phage-Encoded Muramidase, KTN6 Gp46 [PDF]

Endolysins are phage-encoded lytic enzymes that degrade bacterial peptidoglycan at the end of phage lytic cycles to release new phage particles.
van Ryne, Michael, van Ryne, M., De Maesschalck, Vincent, Drulis-Kawa, Zuzanna, Danis-Wlodarczyk, K., De Maesschalck, V., Drulis-Kawa, Z., Sanz-Gaitero, Marta, Rodriguez-Rubio, Lorena, Van Noort, Vera, Van Noort, V., van Raaij, Mark, Patel, A., Mesnage, Stephane, Sanz-Gaitero, M., van Raaij, M., Lavigne, Rob, Longin, H., Danis-Wlodarczyk, Katarzyna, Patel, Ankur, Longin, Hannelore, Lavigne, R., Rodriguez-Rubio, L., Mesnage, S.   +23 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Isolation and characterization of a T7-like lytic phage for Pseudomonas fluorescens [PDF]

BMC Biotechnology, 2008
AbstractBackgroundDespite the proven relevance ofPseudomonas fluorescensas a spoilage microorganism in milk, fresh meats and refrigerated food products and the recognized potential of bacteriophages as sanitation agents, so far no phages specific forP.
Sillankorva, Sanna, Neubauer, P., Azeredo, Joana   +2 more
openaire   +4 more sources

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment

, 2013
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Pérez, Ma. Teresa, Imamovic, Lejla   +1 more
core   +1 more source

Toward Understanding Phage:Host Interactions in the Rumen; Complete Genome Sequences of Lytic Phages Infecting Rumen Bacteria

Frontiers in Microbiology, 2017
The rumen is known to harbor dense populations of bacteriophages (phages) predicted to be capable of infecting a diverse range of rumen bacteria. While bacterial genome sequencing projects are revealing the presence of phages which can integrate their ...
Rosalind A. Gilbert, Rosalind A. Gilbert, William J. Kelly, Eric Altermann, Eric Altermann, Sinead C. Leahy, Sinead C. Leahy, Catherine Minchin, Diane Ouwerkerk, Diane Ouwerkerk, Athol V. Klieve, Athol V. Klieve   +11 more
doaj   +1 more source