Results 61 to 70 of about 30,001 (226)

Rapid and quantitative phage susceptibility test by ramanome

mLife, EarlyView.
Abstract Antimicrobial resistance poses an escalating global threat, renewing interest in bacteriophage therapy as a precision alternative to antibiotics. However, clinical translation remains hindered by the lack of rapid and quantitative phage susceptibility testing (PST) platforms capable of evaluating host range, infection potency, and effective ...
Xiao Han, Xiaofu Wan, Yang Zhou, Xiaoting Fu, Xiaoshan Zheng, Bo Gao, Shi Huang, Anle Ge, Jiadong Huang, Hongzhou Lu, Jian Xu   +10 more
wiley   +1 more source

Exploring phage mechanisms that enhance activity

, 2017
In recent years, there has been a renewed interest in using bacteriophages as an alternate agent for the treatment of multi-drug resistant bacteria. One such highly drug-resistant group of bacteria is the Burkholderia cepacia complex (Bcc), which causes ...
Kamal, Fatima
core   +1 more source

Isolation and characterization of new lytic bacteriophage PSA-KC1 against Pseudomonas aeruginosa isolates from cystic fibrosis patients

Scientific Reports
A novel lytic bacteriophage, PSA-KC1, was isolated from wastewater. In this study, the whole genome of the bacteriophage PSA-KC1 was analyzed, and its lytic properties were assessed.
Kübra Can Kurt, Halil Kurt, Edip Tokuç, Doğukan Özbey, Duygu Nur Arabacı, Sevcan Aydın, Nevriye Gönüllü, Mikael Skurnik, Hrisi Bahar Tokman   +8 more
doaj   +1 more source

Formation of therapeutic phage cocktail and endolysin to highly multi-drug resistant Acinetobacter baumannii: in vitro and in vivo study [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and ...
Hayder Nsaif Jasim, Rand Riadh Hafidh, Ahmed Sahib Abdulamir   +2 more
doaj   +1 more source

Phage single-stranded DNA-binding protein or host DNA damage triggers the activation of the AbpAB phage defense system

mSphere, 2023
Bacteria have developed various defense mechanisms against phages. Abortive infection (Abi), a bacterial defense mechanism, can be achieved through various means, including toxin-antitoxin systems, cyclic oligonucleotide-based antiphage signaling systems,
Takaomi Sasaki, Saya Takita, Takashi Fujishiro, Yunosuke Shintani, Satoki Nojiri, Ryota Yasui, Tetsuro Yonesaki, Yuichi Otsuka   +7 more
doaj   +1 more source

Biochemical and structural characterization of a tail‐spike protein with depolymerase activity identified in a marine podovirus

Acta Crystallographica Section D, EarlyView.
The marine tail‐spike protein Dpo31 degrades the exopolysaccharide of its host and has structural features similar to those of other members of this protein class, despite similarity not being detected at the sequence level.Marine phages are, through the infection of their bacterial hosts, key regulators of microbiome and carbon fluxes in the ocean ...
Serena Sirigu, Thomas Roret, Pierre-Yves Mocaër, Robert Larocque, Diane Jouanneau, Pierre Legrand, Anne-Claire Baudoux, Mirjam Czjzek   +7 more
wiley   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Lytic Activity of Various Phage Cocktails on Multidrug-Resistant Bacteria

, 2016
Purpose: A bacteriophage is a virus that infects and replicates within a bacterium following the injection of phage genome into the bacterial cytoplasm. They are seen as a possible therapy for multi-drug-resistant strains of many bacteria.
Akturk, E, Yeshenkulov, N, Rahmanov, N, Ozkan, I, Atabay, H I, Atmaca, S   +5 more
core   +2 more sources

PhalydDB, A massive phage-derived lytic protein database for enzybiotics design and bacterial host prediction

, 2022
 4,594, 16,453, and 108,967 phage nucleotide sequences from three separate sources (INPHARED, phage genomes from Millardlab and GPD & MGV) were comprehensively evaluated for the construction of Phage Lysin-associated Domain and Bacterial Host Prediction ...
Jiewen Huang (13898655), Cheng Chang (13898675), Chao Lv (13898652), Enhao Li (13898562), Jingyang Tu (13898621), Hongquan Gou (13898616), Min Li (13898639), XiaoKui Guo (13898658), Qingtian Li (13898660), Shiyun Wang (13898649), Wennan Guo (13898677), Yi Rong (13898644), Yilun Xue (13898646), Yihui Zhang (13898648), Yongzhang Zhu (13898662)   +14 more
core   +1 more source

Lytic Phages against ST11 K47 Carbapenem-Resistant Klebsiella pneumoniae and the Corresponding Phage Resistance Mechanisms

mSphere, 2022
We isolated and characterized a novel phage from hospital sewage, P13, able to lyse ST11 K47 carbapenem-resistant Klebsiella pneumoniae (CRKP), a major CRKP lineage.
Qingqing Fang, Zhiyong Zong
doaj   +1 more source