Results 51 to 60 of about 30,001 (226)

Characterization of a Broad-Host-Range Lytic Phage SHWT1 Against Multidrug-Resistant Salmonella and Evaluation of Its Therapeutic Efficacy in vitro and in vivo

Frontiers in Veterinary Science, 2021
Inappropriate use of antibiotics has accelerated to the emergence of multidrug-resistant bacteria, becoming a major health threat. Moreover, bacterial biofilms contribute to antibiotic resistance and prolonged infections.
Chenglin Tao, Chenglin Tao, Zhengfei Yi, Yaodong Zhang, Yao Wang, Hong Zhu, Dossêh Jean Apôtre Afayibo, Tao Li, Mingxing Tian, Jingjing Qi, Chan Ding, Chan Ding, Song Gao, Shaohui Wang, Shengqing Yu, Shengqing Yu   +15 more
doaj   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Lytic potential of phage KO mutants.

, 2016
Lytic potential of phage KO mutants.
Chad W. Euler (401322), Douglas R. Deutsch (588547), Barbara Juncosa (845373), Patricia A. Ryan (401323), Vincent A. Fischetti (57436), W. Michael McShan (839517)   +5 more
core   +1 more source

Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease

Annals of Neurology, EarlyView.
We conducted a nested case‐control study within the Nurses’ Health Study and the Health Professionals Follow‐up Study to examine the role of the gut virome (GV) in Parkinson's disease (PD). We applied a novel metagenomic virome profiling approach, Bioinformatic Application for Quantification and Labeling of Viral taxonomy (BAQLaVa), to prospectively ...
Deepika Dinesh, Xochitl C. Morgan, Jordan Jensen, Kjetil Bjornevik, Michael A. Schwarzschild, Alberto Ascherio, Curtis Huttenhower, Natalia Palacios   +7 more
wiley   +1 more source

Application of a Phage Cocktail for Control of Salmonella in Foods and Reducing Biofilms

, 2019
Salmonella contamination in foods and their formation of biofilms in food processing facility are the primary bacterial cause of a significant number of foodborne outbreaks and infections.
Yan, Ting, Wang, Xiaohong, Jinquan Li, Kun Liu, Li, Jinquan, Liang, Lu, Yang Zhou, Lu Liang, Nime, Ishatur, Liu, Kun, Zhou, Yang, Ting Yan, Xiaohong Wang, Islam, Md. Sharifull, Md. Sharifull Islam, Ishatur Nime   +15 more
core   +1 more source

Comparative genomics defines the core genome of the growing N4-like phage genus and identifies N4-like Roseophage specific genes [PDF]

, 2014
Two bacteriophages, RPP1 and RLP1, infecting members of the marine Roseobacter clade were isolated from seawater. Their linear genomes are 74.7 and 74.6 kb and encode 91 and 92 coding DNA sequences, respectively.
Schäfer, Hendrik, Jacqueline Zoe-Munn Chan, Nicholas Harold Mann, Chan, Jacqueline, Andrew David Millard, Millard, Andrew D., Jacqueline Z.-M. Chan, Mann, Nicholas H., Hendrik eSchäfer, Andrew D. Millard, Nicholas H. Mann, Hendrik Schäfer   +11 more
core   +1 more source

The Novel Enterococcus Phage vB_EfaS_HEf13 Has Broad Lytic Activity Against Clinical Isolates of Enterococcus faecalis

Frontiers in Microbiology, 2019
Enterococcus faecalis is a Gram-positive, facultative anaerobic bacterium frequently found in the gastrointestinal tract, oral cavity, and periodontal tissue.
Dongwook Lee, Jintaek Im, Hongjun Na, Sangryeol Ryu, Cheol-Heui Yun, Seung Hyun Han   +5 more
doaj   +1 more source

Characterization of a lytic Pseudomonas aeruginosa phage vB_PaeP_ASP23 and functional analysis of its lysin LysASP and holin HolASP

Frontiers in Microbiology, 2023
In this study, we isolated a lytic Pseudomonas aeruginosa phage (vB_PaeP_ASP23) from the sewage of a mink farm, characterized its complete genome and analyzed the function of its putative lysin and holin.
Jiaqi Cui, Xiaojie Shi, Xinwei Wang, Huzhi Sun, Yanxin Yan, Feiyang Zhao, Can Zhang, Wenhua Liu, Ling Zou, Lei Han, Qiang Pan, Huiying Ren   +11 more
doaj   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Phage lytic proteins: biotechnological applications beyond clinical antimicrobials [PDF]

Critical Reviews in Biotechnology, 2015
Most bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram-positive bacteria resulting in cell lysis when they are applied externally. Bacteriophage lytic proteins have a demonstrated potential in treating animal
Rodríguez, Lorena, Gutiérrez, Diana, Donovan, David M., Martínez Fernández, Beatriz, Rodríguez González, Ana, García Suárez, María Pilar   +5 more
openaire   +3 more sources