Results 71 to 80 of about 2,735,014 (284)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patterns for Authentication and Authorisation Infrastructures [PDF]

open access: yes, 2007
In line with the growing success of e-commerce demands for an open infrastructure providing security services are growing stronger. Authentication and Authorisation Infrastructures (AAIs) enhanced with an attribute-based access control model (ABAC) offer
Günther Pernul   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

A Blockchain-Based Security Model for Aquatic Product Transactions Based on VRF-ZKP and Dynamic Reputation

open access: yesMathematics
With the rapid development of online aquatic product trading, traditional centralized platforms are facing increasing pressure in terms of data security, privacy protection, and trust.
Luxi Yu   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Justification of Methodological Approaches to Identification Testing of Biomedical Cell Products

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2019
The manufacturer (developer) has to prepare a specification for each newly developed biomedical cell product (BCP) that has passed the stage of preclinical studies.
E. V. Melnikova   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Scalable Group Authentication Protocol for IoT Based on PUF-Derived Bases in Inner Product Spaces

open access: yesCybersecurity
This paper presents a scalable group authentication and key agreement protocol for dynamic IoT environments that integrates Physical Unclonable Function (PUF)-derived device bases with inner product space projections.
Pan Feng   +5 more
doaj   +1 more source

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