Results 61 to 70 of about 395,210 (259)

Rapid computation and visualization of data from Kano surveys in R

open access: yesBMC Research Notes, 2018
Objective The Kano model for user satisfaction is a popular survey-based method used by product designers to prioritize the inclusion and implementation of product features based on users’ requirements.
Reynir S. Atlason, Davide Giacalone
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Iterative decoding of SOVA and LDPC product code for bit-patterned media recoding

open access: yesAIP Advances, 2018
The demand for high-density storage systems has increased due to the exponential growth of data. Bit-patterned media recording (BPMR) is one of the promising technologies to achieve the density of 1Tbit/in2 and higher.
Seongkwon Jeong, Jaejin Lee
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Construction of New Matrix-Product Codes and Their Applications

open access: yesIEEE Access, 2019
In this paper, from special code chains $\mathcal {C}_{1} \supseteq \mathcal {C}_{2}~\supseteq \mathcal {C}_{3}$ such that $\mathcal {C}^{\bot _{h}}_{1}\subseteq \mathcal {C}_{3}$ and $\mathcal {C}^{\bot _{h}}_{2}\subseteq \mathcal {C}_{2}$ , some ...
Hao Song   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

High performance short-block binary regular LDPC codes

open access: yesAlexandria Engineering Journal, 2018
LDPC code shows a good performance with long-block codes. However, certain channels are constrained to use short-block codes due to latency. Therefore, concatenated LDPC codes with iterative decoding is a good choice to get a good performance ...
Latifa Mostari, Abdelmalik Taleb-Ahmed
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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