Results 141 to 150 of about 1,544,891 (313)

Exploiting popular culture : exploring pedagogical and motivational approaches for design and technology education

open access: yes, 2007
This paper describes a case study of pedagogical developments carried out with teachers and secondary school students in response to new curriculum content in Product Design courses presented in Scottish secondary schools.
McLaren, Susan, McLaren, Susan V.
core   +1 more source

Dual-structure-breaking electrolyte enables practical cadmium-metal battery

open access: yesNature Communications
High-energy aqueous metal batteries are promising candidates for the next-generation energy storage systems but face critical challenges of dendrite and corrosion in metal negative electrodes.
Yang-Feng Cui   +8 more
doaj   +1 more source

Ethical Principles in AI Use for Assessment: Exploring Students’ Perspectives on Ethical Principles in Academic Publishing

open access: yesEducation Sciences
Students’ comprehension of ethical principles and their application in the realm of AI technology play a crucial role in shaping the efficacy and morality of assessment procedures.
Alexandra Maria Lazăr (Cățeanu)   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Reconfigurable Robotic Exercising Companion

open access: yesApplied Sciences
Regular exercise plays a crucial role in promoting overall well-being in today’s lifestyle. However, individuals often find it challenging to properly execute exercises, including maintaining correct postures and appropriate movement speeds.
W. K. R. Sachinthana   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Design Interference Detector-A Tool for Predicting Intrinsic Design Failures [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityIntricate failures at the system integration phase of the design are mostly generated by interactions of product modules or/and engineering domains.
D’Amelio, V., Tomiyama, Tetsuo
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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