Results 151 to 160 of about 1,544,891 (313)
Mobile collaborative working environment of product design
, 2009 In response to the arrival of new Web/Internet environments, one of the most attractive challenges in current research is to exploit wireless computing technologies in collaborative product design, and hence to build a ubiquitous mobile information ...
Zheng, Yongjun, Zheng, Y
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The impact of buying intention of global fashion on local substitute: The role of product design and price. [PDF]
Heliyon, 2023 Zuliarni S +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Strategies for teaching sustainable design practice with product design students
, 2008 Teaching students how to tackle the issu e of producing practical, commercial product designs that respond to the sustainability impe rative is an important challenge for design educators at this time.
Loy, Jennifer
core
Business Implications of Integrated Product and Service Offerings [PDF]
, 2009 Organised by: Cranfield UniversityThis paper explores the business implications of Integrated Product and Service Offerings (IPSOs). The objective is to show examples of the business implications of IPSOs from a supplier’s perspective, and to suggest ...
Lindahl, Mattias +5 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Retracted: Design for Bedridden Elderly: Presenting Pressure Ulcer Product Design Based on Anthropometric Characteristics. [PDF]
Comput Intell Neurosci, 2023 Intelligence And Neuroscience C.
europepmc +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Retracted: The Impact of Cultural Creative Product Design for Sport Events on the Residents' Fitness. [PDF]
J Environ Public Health, 2023 Environmental And Public Health JO.
europepmc +1 more source