Results 171 to 180 of about 12,719,567 (285)

Security Driven Product Design for Open-Source Medical Syringe Infusion Pumps. [PDF]

Integr STEM Educ Conf
Lu W, Colon E, Fitzpatrick J, Hix L, Mead C.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The application of artificial intelligence-assisted technology in cultural and creative product design. [PDF]

Sci Rep
Liang J.
europepmc   +1 more source

Promoting Protein Intake in an Ageing Population: Product Design Implications for Protein Fortification. [PDF]

Nutrients, 2022
Norton V, Lignou S, Methven L.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

LCD-AHP-TRIZ methodology enhances low-carbon principles in smart product design. [PDF]

Sci Rep
Xu HZ, Chen J.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

EEG assessment of artificial intelligence-generated content impact on student creative performance and neurophysiological states in product design. [PDF]

Front Psychol
Wang S, Tao X, Ma H, Li F, Wu C.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Perspectives on Drug Product Design Among Patients with Lung Cancer in the United Kingdom. [PDF]

Pulm Ther
Coulter JR, Baig LE, Antipas A, Montague D, Terry A, Dews SA, Ogden-Barker M, Doody C, Hauber B.   +8 more
europepmc   +1 more source