Results 241 to 250 of about 4,729,806 (295)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

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Designer-moderated product design

IEEE Transactions on Engineering Management, 2001
A well-designed product can provide a firm with a competitive advantage that will enable it to achieve a higher market share and increased profits. Conjoint analysis procedures are often used for product design. Numerous methods have been developed to take conjoint data and produce optimal or near-optimal product designs.
P. Tarasewich, S.K. Nair
openaire   +1 more source

Design formulae of product design production manufacturability

Science intensive technologies in mechanical engineering, 2020
There are shown basic drawbacks of the well-known factors of manufacturability. The formulae of manufacturability factors excluding mentioned drawbacks and taking into account the impact of product design characteristics upon complete laboriousness of its manufacturing are offered.
openaire   +1 more source

Product Design

2023
Peter C. Powell, A. Jan Ingen Housz
  +5 more sources

Product Design

2007
A good design is both art and science. Creativity is needed to come up with a product concept that has either not been considered before or has been considered and abandoned. Discipline is needed to investigate and evaluate all the details to make sure that they fit together, which is an exercise in multiscale optimization: the product structure is in ...
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Material – Design – Production

Materialwissenschaft und Werkstofftechnik, 1977
openaire   +1 more source

Product Design

2015
Herman Vromans, Giovanni Pauletti
  +4 more sources