Results 121 to 130 of about 3,869,855 (327)

A Framework for Auditing Robot-Inclusivity of Indoor Environments Based on Lighting Condition

Buildings
Mobile service robots employ vision systems to discern objects in their workspaces for navigation or object detection. The lighting conditions of the surroundings affect a robot’s ability to discern and navigate in its work environment. Robot inclusivity
Zimou Zeng, Matthew S. K. Yeo, Charan Satya Chandra Sairam Borusu, M. A. Viraj J. Muthugala, Michael Budig, Mohan Rajesh Elara, Yixiao Wang   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Portable robots for upper-limb rehabilitation after stroke: a systematic review and meta-analysis

Annals of Medicine
Background Robot-assisted upper-limb rehabilitation has been studied for many years, with many randomised controlled trials (RCTs) investigating the effects of robotic-assisted training on affected limbs.
Kevin C. Tseng, Le Wang, Chunkai Hsieh, Alice M. Wong   +3 more
doaj   +1 more source

New Product development in a platform-driven organization : Towards platform lifecycle management [PDF]

Platform product development is now widely used to tackle the cost-variety dilemma. In this work, we questioned the planning hypothesis underlying most of the research on platform design.
Caroline Derousseaux, Sihem Ben Mahmoud-Jouini, Sylvain Lenfle   +2 more
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Evaluating the Robot Inclusivity of Buildings Based on Surface Unevenness

Applied Sciences
Mobile service robots experience excessive vibrations when travelling over uneven surfaces in their workspace, increasing the degradation rate of the mechanical components or disrupting the robot’s sensing abilities for proper localization and ...
Charan Satya Chandra Sairam Borusu, Matthew S. K. Yeo, Zimou Zeng, M. A. Viraj J. Muthugala, Michael Budig, Mohan Rajesh Elara, Yixiao Wang   +6 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Adaptive Outdoor Cleaning Robot with Real-Time Terrain Perception and Fuzzy Control

Mathematics
Outdoor cleaning robots must operate reliably across diverse and unstructured surfaces, yet many existing systems lack the adaptability to handle terrain variability.
Raul Fernando Garcia Azcarate, Akhil Jayadeep, Aung Kyaw Zin, James Wei Shung Lee, M. A. Viraj J. Muthugala, Mohan Rajesh Elara   +5 more
doaj   +1 more source

Improving outcomes in outsourced product development: a joint consultant-client perspective [PDF]

, 2010
Although firms increasingly outsource front end product development activities to production suppliers or design consultants, this practice has received little scholarly attention. The few existing academic studies report high failure rates but generally
Palm, William J., Whitney, Daniel E.
core   +1 more source