Results 241 to 250 of about 6,311,964 (280)

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

From an idea to the marketplace: Identifying and addressing ethical and regulatory considerations across the digital health product-development lifecycle. [PDF]

BMC Digit Health
Largent EA, Karlawish J, Wexler A.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A patient safety knowledge graph supporting vaccine product development. [PDF]

BMC Med Inform Decis Mak
Simms AM, Kanakia A, Sipra M, Dutta B, Southall N.   +4 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

A weighted fuzzy approach for the agility of sustainable product development process assessment: A case study in Chinese medium-sized enterprises. [PDF]

Heliyon
Zhining Z, Alli H, Ahmadipour M, Che Me R.   +3 more
europepmc   +1 more source

Enabling product development partnerships to bring forward the next generation of health technologies. [PDF]

Health Aff Sch
So AD, Woo J, Helble M.
europepmc   +1 more source

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Microbicide product development

Current Opinion in HIV and AIDS, 2008
The purpose of this overview is to summarize the essential parameters needed to establish a sound microbicide development strategy.In recent years more comprehensive regulatory guidelines that are applicable to microbicides have been developed. Additionally, the US Food and Drug Administration have begun providing specific guidance for microbicide ...
openaire   +2 more sources

Product Development

2009
The Delft architecture firm, cepezed, claims to use an integral design method with multiple material use in which various aspects such as spatial design, construction and installation techniques are forged into an indivisible whole. cepezed preferes construction elements which are prefabricated, wherever possible. The application of components produced
  +5 more sources

Hybrid Sorghum Product Development and Production

2019
There are many moving parts involved in developing and taking a new commercial hybrid to market. Sorghum [Sorghum bicolor (L.) Moench] hybrid development involves development of parental lines based on a cytoplasmic male sterile system including the pollen parent (R-line) and seed parents (A- and B-lines).
openaire   +2 more sources