Results 51 to 60 of about 6,360,422 (309)

A novel approach to collaborative product development in the medical-equipment industry [PDF]

, 2013
In this study, we summarise the requirements for collaborative product development based on our investigation of the differences in the resources and tools that are needed for the various stages of collaborative product development and the needs of ...
Chien-Lung, Hsu, Tseng, Kevin C
core  

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Towards a New Framework for Product Development [PDF]

, 2000
In the mid-1980s, Andreasen and Hein first described their model of Integrated Product Development. Many Danish companies quickly embraced the principles of integrated product development and adapted the model to their specific business and product ...
McAloone, TC, Robotham, AJ
core   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Influence of empty fruit bunch oil on crude palm oil quality and refining characteristics☆

Oilseeds and fats, crops and lipids
This study examined the composition of oil extracted from empty fruit bunches (EFB) and its effects on the refining, fractionation, and occurrence of process-developed contaminants in palm oil.
Ramli Muhamad Roddy, Ahmad Tarmizi Azmil Haizam, Abdul Hammid Abdul Niefaizal, Abd Razak Raznim Arni   +3 more
doaj   +1 more source

Experimental Investigation of a Large Tilting-Pad Journal Bearing—Comparison of a Flooded and Non-Flooded Design

Lubricants, 2022
In tilting-pad journal bearings (TPJB), power loss corresponds to the internal friction in the shearing of the oil. Besides the lubrication gap, intermediate spaces between the pads account for a notable amount of frictional losses.
Michael Stottrop, Nico Buchhorn, Beate Bender   +2 more
doaj   +1 more source

Modelling the Product Development performance of Colombian Companies [PDF]

, 2009
Organised by: Cranfield UniversityThis paper presents the general model of the Product Development Process (PDP) in the Metal mechanics Industry in Barranquilla-Colombia, since this sector contributes significantly to the productivity of this ...
Al-Ashaab, Ahmed, Berdugo, C., Herrera-Hernandez, M. C., Luna, C., Prada, L.   +4 more
core  

Multiobjective strategies for New Product Development in the pharmaceutical industry [PDF]

, 2012
New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline.
Azzaro-Pantel, Catherine, Pibouleau, Luc, Pérez-Escobedo, José Luis   +2 more
core   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source