Results 71 to 80 of about 1,775,217 (266)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

RECOMBINANT MONOCLONAL ANTIBODIES FOR NEUROSCIENCE RESEARCH

IBRO Neuroscience Reports, 2023
Alexander Ball, Yung Lin Hsieh, Chun Kai Huang, Sega Huang, Ping Kuan Hsieh, Shang Ru Wu, Yue Yun Chang, Jiming Liu, Po Shin Peng, Chia Yun Chang, Chia Yi Lin   +10 more
doaj   +1 more source

Bridging HDL Bits and Caffe: An Educational Path to AI Accelerator Design [PDF]

SHS Web of Conferences
An integrated educational pipeline is presented that bridges hardware description language (HDL) exercises with the Caffe deep learning framework, enabling progression from Verilog fundamentals to the deployment of convolutional neural network ...
Shanker Manjusha, Teo Tee Hui, Agarwal Harsh, Elsharkawy Mostafa Osama Abdellatif   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Big BIT maize experiment: A large multi‐location, multi‐year, multi‐tester, multi‐population predictive breeding validation study

The Plant Genome
The Big Breeding Innovation Team (Big BIT) maize (Zea mays L.) experiment was one of the largest genomic data‐informed predictive breeding validation studies ever conducted.
Michael Jines, Michael Chandler, Dean Podlich, Andrew Baumgarten, Deanne Wright, Amy Jacobson, Honghua Zhao, Jared Gogerty, Matthew Regennitter, Hsiao‐Yi Hung, Riley McDowell, Tom Tang, Christine Diepenbrock, Hoda Helmi, Carlos Messina, Andrew Ross, Gary Henke, Lindsay Spangler, Matthew Caldwell, Leah Stirling, Andres Reyes, Carla Gho, Mark Cooper, John Arbuckle, Matthew Smalley, Sandra Milach, Geoff Graham, Liviu Radu Totir   +27 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Determination of Erucamide Slip Additive in Polypropylene Masterbatch: Comparison of Soxhlet and Dissolution-Precipitation Method [PDF]

Journal of Pure and Applied Chemistry Research
Erucamide is a long-chain carboxylic acid amide used as a slip agent in plastic films. In this research, the slip additive in polypropylene masterbatch with 6% erucamide content was extracted by comparing two methods which are dissolution-precipitation ...
Eka L. Purwaningtyas, Debby C. Wahyuni, Muhammad Y. Ramadhan, Silfi V. Susanti, Muhammad N. Ariesta, Chengli, Laily A. Agustina, Rakhma Febriani   +7 more
doaj  

Benchmarking molecular conformer augmentation with context-enriched training: graph-based transformer versus GNN models

Journal of Cheminformatics
The field of molecular representation has witnessed a shift towards models trained on molecular structures represented by strings or graphs, with chemical information encoded in nodes and bonds.
Cecile Valsecchi, Jose A. Arjona-Medina, Natalia Dyubankova, Ramil Nugmanov   +3 more
doaj   +1 more source

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

mAbs, 2020
Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s safety
Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu   +14 more
doaj   +1 more source