Results 91 to 100 of about 6,360,422 (309)

Creating a culture for radical innovation in a small mature business [PDF]

, 2016
This article describes an approach in organizational development to develop an innovation culture for radical product development in a small mature engineering company.
McLaughlin, Patrick
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Integrating computational simulation and high-throughput screening for the development of robust ultra-high concentration formulation of IgG1 antibody

mAbs
High-viscosity monoclonal antibody (mAb) formulations impede injection, complicate manufacturing, and may affect drug stability and patient outcomes. Nevertheless, these issues can be effectively mitigated through the judicious selection of appropriate ...
Chen Lyu, Shuyan Lu, Yiqiu Yin, Hongling Li, Dahui Xing, Yanjie Lu, Shujing Zheng, Qiuyu Zhang, Lingyu Gao, Shuxian Xu, Qian Zou, Feng Liu, Jinliang Zhang, Yun Kang   +13 more
doaj   +1 more source

Traceability for Model Driven, Software Product Line Engineering [PDF]

, 2008
Traceability is an important challenge for software organizations. This is true for traditional software development and even more so in new approaches that introduce more variety of artefacts such as Model Driven development or Software Product Lines ...
Anquetil, N., Arboleda, H., Galvao Lourenco da Silva, I., Garcia, A., Grammel, B., Noppen, J.A.R., Rashid, A., Shakil Khan, S.   +7 more
core   +5 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Gaming techniques and the product development process : commonalities and cross-applications [PDF]

, 2006
The use of computer-based tools is now firmly embedded within the product development process, providing a wide range of uses from visualisation to analysis.
Bradley, D., Wodehouse, A.J.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Application of Tiling Theory for Path Planning Strategy in a Polyiamond Inspired Reconfigurable Robot

IEEE Access, 2019
Commercial floor cleaning robots face significant challenges in accessing convex and narrow corners due to their fixed and regular morphologies. To overcome this, we develop a new class of self-reconfigurable floor cleaning robot, hTetrakis, which is ...
Rizuwana Parween, Veerajagadheswar Prabakaran, Mohan Rajesh Elara, Ayyalusami Vengadesh, Vinu Sivanantham   +4 more
doaj   +1 more source

Design for manufacture and sustainability in new product development [PDF]

, 2010
Design for manufacture is well recognised by industry and is about optimising design to aid production. Today there is a significant and growing trend of recognising what happens to a product once its user phase has finished.
De Coster, R, Griffiths, BJ, Harrison, DJ, Plant, AVC   +3 more
core  

An Adaptive Design Methodology for Reduction of Product Development Risk

, 2011
Embedded systems interaction with environment inherently complicates understanding of requirements and their correct implementation. However, product uncertainty is highest during early stages of development.
Khan, Dr. Ibrahim, Kvsvn, Dr. Raju, Pakala, Hara Gopal Mani, Varaprasad, Dr. Plh   +3 more
core   +1 more source