Results 91 to 100 of about 1,694,885 (313)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Embodied Cognition and New Product Design: Changing Product Form to Influence Brand Categorization
, 2020 This article explains how embodied cognition and perceptual symbol systems enable product designers to influence consumers by communicating key perceptual features through subtle changes in product design elements.
Malter, AJ, Kreuzbauer, R
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
On contact CR-submanifolds of sasakian manifolds
International Journal of Mathematics and Mathematical Sciences, 1983 Recently, K.Yano and M.Kon [5] have introduced the notion of a contact CR-submanifold of a Sasakian manifold which is closely similar to the one of a CR-submanifold of a Kaehlerian manifold defined by A. Bejancu [1].
Koji Matsumoto
doaj +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2016 An integrated fuzzy-based Taguchi method (TM) for multi-response optimization of product form design is presented in this paper. The fuzzy-based TM is applied to determine the optimum combination of design parameters for product form design which will ...
Sugoro Bhakti SUTONO +3 more
doaj +1 more source
, 1994 . The product form results recently published for Stochastic Petri Nets are combined with the well known product form results for Queueing Networks in the model formalism of Queueing Petri Nets yielding the class of product form Queueing Petri Nets. This
Falko Bause +2 more
core
Finite form of the quintuple product identity
Journal of Combinatorial Theory, Series A, 2006 1 ...
CHU, Wenchang, Chen Y. C., Gu S. S.
openaire +3 more sources