Results 101 to 110 of about 427,530 (307)
Scientific ReportsThe vasodilatory and neuroprotective properties of felodipine were characterized in normal and ischemic rabbit eyes, an ocular hypertension (OHT) rat model, and cultured human neuron-like cells. Blood flow in the optic nerve head (ONH) was measured using
Takazumi Taniguchi +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Masters of War: Rivals’ Product Innovation and New Advertising in Mature Product Markets. [PDF]
We investigate the impact of rivals' product innovation and new advertising on a firm's financial market value in mature product markets. Our test bed is the carbonated soft drink market between 1999 and 2003, a period characterized by a near duopoly ...
Fosfuri, Andrea, Giarratana, Marco S.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Determinants of product innovation in small firms: A Comparison Across Industries [PDF]
A plethora of studies has investigated the determinants of product innovation in small firms, suggesting product, firm, market and innovation process factors as its key drivers of success.
Jeroen de Jong, Patrick Vermeulen
core
An Extended AI-Experience: Industry 5.0 in Creative Product Innovation. [PDF]
Sensors (Basel), 2023 Grech A, Mehnen J, Wodehouse A.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
BLACK SEA: EUROPEAN TOURISM AND PRODUCT INNOVATION [PDF]
Nowadays, tourism is a dynamic industry that implies continued challenges for the companies in the field. As the tourist experience evolves, technology develops, and the quality of life rises, tourists have more and more sophisticated and complex tastes ...
Daniela Firoiu, Patricia Dodu
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
The impact of smart city Internet firms network embeddedness on product innovation: a moderated mediating model. [PDF]
Soft comput, 2023 Sun C.
europepmc +1 more source