Results 81 to 90 of about 1,727,218 (301)

Characteristics of effective design support: insights from evaluating additive manufacturing design artefacts

Design Science
Evaluation approaches are needed to ensure the development of effective design support. These approaches help developers ensure that their design support possesses the general design support characteristics necessary to enable designers to achieve their ...
Didunoluwa Obilanade, Peter Törlind, Christo Dordlofva   +2 more
doaj   +1 more source

"Silver" product design: Product innovation for older people [PDF]

Aging populations challenge companies across different countries and industries to respond to the changing needs, demands and expectations of their growing shares of older customers.
Bauer, Patrick, Herstatt, Cornelius, Kohlbacher, Florian   +2 more
core  

Creating a culture for radical innovation in a small mature business [PDF]

, 2016
This article describes an approach in organizational development to develop an innovation culture for radical product development in a small mature engineering company.
McLaughlin, Patrick
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cross-Domain Bearing Fault Diagnosis Under Class Imbalance: A Dynamic Maximum Triple-View Classifier Discrepancy Network

Algorithms
Traditional domain adaptation methods often assume balanced data distributions. However, this assumption is frequently violated in real-world industrial scenarios, where normal samples predominate while fault samples are inherently scarce.
Rui Luo, Huiyang Xie, Haitian Wen, Hongying He, Yitong Li, Kai Wang   +5 more
doaj   +1 more source

Shift from Product Innovation Strategy to Marketing Innovation Strategy to Add Value to the Firm

Management Dynamics in the Knowledge Economy, 2022
This article explores the role of innovation strategies for enhancing the competitiveness of SMEs in global markets. Based on a literature review of innovation strategies, these strategies were separated into four groups: product innovation, process ...
Fatima BOUHELAL, Lakhdar ADOUKA
doaj  

Product and Process Innovations in a Horizontally Differentiated Product Market [PDF]

For a market of horizontal product differentiation, the paper examines the effects of the level of competition on the firm’s decision between a product and process innovation.
Pia Weiss
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Simulation and Analysis of Different Bipolar Plate Geometrical Parameters on the Performance of PEM Fuel Cells Applying the Taguchi Method

Energies
This study examines the impact of key stamping process parameters on metallic bipolar plates for Proton Exchange Membrane Fuel Cell (PEMFC) performance using computational fluid dynamics (CFD) combined with thermal and electrochemical simulations and ...
Raquel Busqué, Matias Bossio, Enric Rovira, Albert Brigido   +3 more
doaj   +1 more source