Results 91 to 100 of about 1,727,218 (301)

Comprehensive Innovation and its Implications on New High-Tech Product Development [PDF]

Nowadays, innovation represents an essential ingredient within organizations for their survival in a strong competitive marketplace. Innovations emerging from R&D projects could represent key factors for the foundation of new businesses.
Stelian BRAD
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Felodipine re-positioned as a neuroprotectant via improved optic nerve head blood circulation in retinal ischemic rabbits and ocular hypertensive rats

Scientific Reports
The vasodilatory and neuroprotective properties of felodipine were characterized in normal and ischemic rabbit eyes, an ocular hypertension (OHT) rat model, and cultured human neuron-like cells. Blood flow in the optic nerve head (ONH) was measured using
Takazumi Taniguchi, Takahiro Akaishi, Tatsuya Hata, Rieko Yamashita, Yoshihiko Esaki, Ryo Morofuji, Komei Okabe, Masahiro Fuwa, Yasuko Yamamoto, Li Guo, Soyoung Choi, Vy Luong, Takashi Ota, Najam A. Sharif, M. Francesca Cordeiro, Masaaki Kageyama   +15 more
doaj   +1 more source

Integrated Product Policy and Environmental Product Innovations: An Empirical Analysis [PDF]

The European Commission has recently stepped up its promotion of the ?Integrated Product Policy?. The objective of the IPP is to support the realisation of environmental product innovations and thus to achieve a broad reduction of all environmental ...
Rehfeld, Katharina-Maria, Rennings, Klaus, Ziegler, Andreas   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Masters of War: Rivals’ Product Innovation and New Advertising in Mature Product Markets. [PDF]

We investigate the impact of rivals' product innovation and new advertising on a firm's financial market value in mature product markets. Our test bed is the carbonated soft drink market between 1999 and 2003, a period characterized by a near duopoly ...
Fosfuri, Andrea, Giarratana, Marco S.
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

An Extended AI-Experience: Industry 5.0 in Creative Product Innovation. [PDF]

Sensors (Basel), 2023
Grech A, Mehnen J, Wodehouse A.
europepmc   +1 more source

Effects of Innovation on Employment: A Dynamic Panel Analysis [PDF]

This paper estimates the effect of innovation on employment at the firm level. Our uniquely long innovation panel data set of German manufacturing firms covers more than 20 years and allows us to use various innovation measures.
Horst Rottmann, Stefan Lachenmaier
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source