Results 71 to 80 of about 9,267 (212)

EFFECT OF CORPORATE INNOVATION ABILITY ON THE CHOICE BETWEEN PRODUCT INNOVATION AND PROCESS INNOVATION

Revista Administração em Diálogo, 2010
With the method of duopoly game theory, the effect of firms’ innovation ability on the choice between product and process innovation is studied. The concept of cost coefficient of product innovation is introduced, and the criterion equation for the ...
Zeng Wu, Tian Zhilong
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Characteristics of effective design support: insights from evaluating additive manufacturing design artefacts

Design Science
Evaluation approaches are needed to ensure the development of effective design support. These approaches help developers ensure that their design support possesses the general design support characteristics necessary to enable designers to achieve their ...
Didunoluwa Obilanade, Peter Törlind, Christo Dordlofva   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cross-Domain Bearing Fault Diagnosis Under Class Imbalance: A Dynamic Maximum Triple-View Classifier Discrepancy Network

Algorithms
Traditional domain adaptation methods often assume balanced data distributions. However, this assumption is frequently violated in real-world industrial scenarios, where normal samples predominate while fault samples are inherently scarce.
Rui Luo, Huiyang Xie, Haitian Wen, Hongying He, Yitong Li, Kai Wang   +5 more
doaj   +1 more source

Shift from Product Innovation Strategy to Marketing Innovation Strategy to Add Value to the Firm

Management Dynamics in the Knowledge Economy, 2022
This article explores the role of innovation strategies for enhancing the competitiveness of SMEs in global markets. Based on a literature review of innovation strategies, these strategies were separated into four groups: product innovation, process ...
Fatima BOUHELAL, Lakhdar ADOUKA
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Simulation and Analysis of Different Bipolar Plate Geometrical Parameters on the Performance of PEM Fuel Cells Applying the Taguchi Method

Energies
This study examines the impact of key stamping process parameters on metallic bipolar plates for Proton Exchange Membrane Fuel Cell (PEMFC) performance using computational fluid dynamics (CFD) combined with thermal and electrochemical simulations and ...
Raquel Busqué, Matias Bossio, Enric Rovira, Albert Brigido   +3 more
doaj   +1 more source