Results 111 to 120 of about 1,705,902 (280)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Product Champion Characteristics in France and Germany. [PDF]

open access: yes
This study examines the relationship between the status and seniority of product champions, their cultural context and the ability of product champions to enlist top management support for an innovation project.
Roure, Lionel
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

The identification of dynamic product innovation opportunities using the multi-phase QFD: the customer requirement and technology development perspectives

open access: yesHumanities & Social Sciences Communications
Identifying product innovation opportunities is critical for companies to implement product innovation activities. However, existing studies primarily identify product innovation opportunities from the perspective of customer requirements or technology ...
Lu Zheng, Lin Sun, Zhen He, Shuguang He
doaj   +1 more source

Incentives and uncertainty: an empirical analysis of the impact of demand on innovation [PDF]

open access: yes
demand, product innovation, process ...
Marco Guerzoni, Roberto Fontana
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Innovation, Income Distribution, and Product Variety [PDF]

open access: yes
On the basis of a modification of K. Lancaster's characteristics approach and a special class of non-homothetic utility functions individual demand functions are derived.
Rainer Vosskamp
core  

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