Results 131 to 140 of about 103,011 (308)
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
The Determinants of Environmental Innovations and Patenting: Germany Reconsidered [PDF]
This paper provides new evidence on the objectives and determinants of different typesof innovations and patents, environmental as opposed to other innovations and patents,and different variants of environmental innovations and patents.
Frank Goetzke, Tilmann Rave, Mario Larch
core
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
The Diffusion of Product Innovations and Market Structure [PDF]
In this paper I analyze the diffusion of a product innovation that was recently made available for licensed purchase within an industry with identical firms producing the same good.
Idu, Roxana
core
Commercializing Sustainable Innovations in the Market through Entrepreneurship [PDF]
, 2009 Organised by: Cranfield UniversityThe system innovations for sustainability require changes at multiple-domains (social, cultural, institutional and technological) and multiple-levels (micro-, meso-, and macro-levels) of the socio-technological system.
Keskin, D., Brezet, H., Diehl, J. C.
core
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
A Percolation Model of the Product Lifecycle [PDF]
The product lifecycle model can be understood as a three-stage model of technological development associated with a particular product technology. In the explorative stage many different designs are developed, in the development stage products become ...
Gerald Silverberg +2 more
core +2 more sources
Product Innovation and Firm Growth: Evidence from the Integrated Circuits Industry [PDF]
Applied research on growth and innovation seems to suggest that successful innovations do not significantly enhance firm growth. This paper tests the hypothesis that the level of observation at which applied research is typically conducted hampers ...
Marco Corsino
core
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source