Results 41 to 50 of about 20,116,479 (227)
Generic PLM system for SMEs: Application to an equipment manufacturer [PDF]
, 2012 For several years, digital engineering has increasingly taken a more important place in the strategic issues of mechanical engineering companies.
Delplace, Jean-Charles +4 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
THE EMERGENCE AND EVOLUTION OF MODERN COSTING METHODS: A HISTORICAL PERSPECTIVE
Kadim Akademi SBDThis study examines the historical development of cost accounting and aims to explain the transition from traditional to modern costing methods after the 1950s.
Mehmet Murat Gutnu
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
MALİYET MUHASEBESİ BAKIŞ AÇISI İLE İŞLETMELERDE ÇEVRE MALİYETLERİ VE YÖNETİMİ
Sosyal Ekonomik Araştırmalar Dergisi, 2013 Tüm dünyada doğal kaynakların hızla tüketilmesi ve kirletilmesi sonucu ekolojik dengenin bozulmaya başlaması ile birlikte; işletmelerde sürdürülebilir kalkınma anlayışı ve çevre koruma bilinci önem kazanmaya başlamıştır. Çevre dostu ürünlere olan talebin
Ali Alagöz, Duygu İrdi̇ren
doaj +4 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
LIFE CYCLE COSTING AS A SYSTEM OF COSTS FORMATION OF RESEARCH AND DEVELOPMENT
Вестник университета, 2019 In the article, the possibilities of using Life Cycle Costing (LCC) method when forming costs of research and development are considered. Authors have investigated the fields using of this method and conclusions are drawn on impossibility of his ...
Y. Vorontsova, A. Korchagina
doaj
المجلة الدولية للأداء الاقتصادي, 2023 The study is dealt with an important topic related to one of the developments that occurred in the modern business environment (which represents one of the strategies to achieve competitive advantage) due to its importance and its relationship to the ...
Zeyad Hashim ALSAQA
doaj
Life cycle cost estimation in product-service systems: a review of machine learning methods
Proceedings of the Design SocietyABSTRACT: Cost planning for Product-Service Systems faces rising complexity, making life-cycle cost estimates essential. This paper investigates how machine learning (ML) can be applied for life-cycle cost estimation in product development. A literature review was conducted to identify ML-based methods, classify them across life cycle
Daniel Rosemann +3 more
openaire +1 more source