Results 101 to 110 of about 788,228 (290)

Recurrence Relations for Moments and Estimation of Parameters of Extended Exponential Distribution Based on Progressive Type-II Right-Censored Order Statistics

Journal of Statistical Theory and Applications (JSTA)
In this article we derive the recurrence relations for the single and product moments based on progressively Type-II right-censored order statistics for the extended exponential (EE) distribution.
Devendra Kumar, Mansoor Rashid Malik, Sanku Dey, Muhammad Qaiser Shahbaz   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Advancing estimation techniques and their applications in engineering and medical data analysis through novel continuous and discrete linear failure rate distribution extension

Journal of Radiation Research and Applied Sciences
In this paper, we present a new heavy-tailed distribution called the heavy-tailed linear failure rate (HTLFR) distribution. Various statistical properties of the proposed distribution are derived, including the quantile function, the median, the ordinary
Ibrahim Elbatal, Mohammed Elgarhy, Sanaa Mohammed Almarzouki, L.S. Diab, Anis Ben Ghorbal, Ehab M. Almetwally   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

On the Convergence of a Family of Chlodowsky Type Bernstein-Stancu-Schurer Operators

Journal of Function Spaces, 2018
We construct a new family of univariate Chlodowsky type Bernstein-Stancu-Schurer operators and bivariate tensor product form. We obtain the estimates of moments and central moments of these operators, obtain weighted approximation theorem, establish ...
Lian-Ta Shu, Guorong Zhou, Qing-Bo Cai
doaj   +1 more source

The Moment Problem for a Sobolev Inner Product

Journal of Approximation Theory, 1999
The concepts of definite and determinate Sobolev moment problem are introduced. The study of these questions is reduced to the definiteness or determinacy, respectively, of a system of classical moment problems by means of a canonical decomposition of the moment matrix associated with a Sobolev inner product in terms of Hankel matrices.
Rolanı́a, D.Barrios, Lagomasino, G.López, Cabrera, H.Pijeira   +2 more
openaire   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

On powers of Stieltjes moment sequences, II

, 2004
We consider the set of Stieltjes moment sequences, for which every positive power is again a Stieltjes moment sequence, we and prove an integral representation of the logarithm of the moment sequence in analogy to the L\'evy-Khinchin representation.
Berg, Christian
core   +1 more source